On the promise of glycogen phosphorylase inhibition in acute inflammation

On the promise of glycogen phosphorylase inhibition in acute inflammation

How glycogen metabolism directly regulates macrophages in the acute inflammatory state is not well understood. In the recent issue of Nature Communications, Ma et al. provide new insight into this process, demonstrating that glycogenolysis-driven pentose phosphate pathway and UDP-glucose-driven P2Y...

Full description

Bibliographic Details
Main Authors: Aarooran Sivakumaran Durairaj, Paras Singh Minhas
Format: Article
Language:English
Published: SAGE Publishing 2021-03-01
Series:European Journal of Inflammation
Online Access:https://doi.org/10.1177/20587392211001620
id doaj-0181202cc0864dc3909c940291d854f4
record_format Article
spelling doaj-0181202cc0864dc3909c940291d854f42021-03-13T04:04:54ZengSAGE PublishingEuropean Journal of Inflammation2058-73922021-03-011910.1177/20587392211001620On the promise of glycogen phosphorylase inhibition in acute inflammationAarooran Sivakumaran Durairaj0Paras Singh Minhas1Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USAWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USAHow glycogen metabolism directly regulates macrophages in the acute inflammatory state is not well understood. In the recent issue of Nature Communications, Ma et al. provide new insight into this process, demonstrating that glycogenolysis-driven pentose phosphate pathway and UDP-glucose-driven P2Y 14 receptor promote an inflammatory phenotype in macrophages. They show that in vivo blockade of glycogenolysis is sufficient to rescue survival in peritonitis, hepatitis, and sepsis. Their results hold implications for the treatment of acute inflammatory disorders at large.https://doi.org/10.1177/20587392211001620
collection DOAJ
language English
format Article
sources DOAJ
author Aarooran Sivakumaran Durairaj
Paras Singh Minhas
spellingShingle Aarooran Sivakumaran Durairaj
Paras Singh Minhas
On the promise of glycogen phosphorylase inhibition in acute inflammation
European Journal of Inflammation
author_facet Aarooran Sivakumaran Durairaj
Paras Singh Minhas
author_sort Aarooran Sivakumaran Durairaj
title On the promise of glycogen phosphorylase inhibition in acute inflammation
title_short On the promise of glycogen phosphorylase inhibition in acute inflammation
title_full On the promise of glycogen phosphorylase inhibition in acute inflammation
title_fullStr On the promise of glycogen phosphorylase inhibition in acute inflammation
title_full_unstemmed On the promise of glycogen phosphorylase inhibition in acute inflammation
title_sort on the promise of glycogen phosphorylase inhibition in acute inflammation
publisher SAGE Publishing
series European Journal of Inflammation
issn 2058-7392
publishDate 2021-03-01
description How glycogen metabolism directly regulates macrophages in the acute inflammatory state is not well understood. In the recent issue of Nature Communications, Ma et al. provide new insight into this process, demonstrating that glycogenolysis-driven pentose phosphate pathway and UDP-glucose-driven P2Y 14 receptor promote an inflammatory phenotype in macrophages. They show that in vivo blockade of glycogenolysis is sufficient to rescue survival in peritonitis, hepatitis, and sepsis. Their results hold implications for the treatment of acute inflammatory disorders at large.
url https://doi.org/10.1177/20587392211001620
work_keys_str_mv AT aarooransivakumarandurairaj onthepromiseofglycogenphosphorylaseinhibitioninacuteinflammation
AT parassinghminhas onthepromiseofglycogenphosphorylaseinhibitioninacuteinflammation
_version_ 1724222246563610624

Similar Items