MiR-140 targets RAP2A to enable the proliferation of insulin-treated ovarian granulosa cells

MiR-140 targets RAP2A to enable the proliferation of insulin-treated ovarian granulosa cells

Abstract Background We elucidated the role of specific MicroRNAs (miRNAs) in the development of polycystic ovary syndrome (PCOS) and explained the changes in the proliferation of granulosa cells. Excised ovarian cortex specimens were collected for miRNA profiling analysis (n = 20 PCOS females and 5...

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Bibliographic Details
Main Authors: Zhengfang Xiong, Bing Li, Wenjuan Wang, Xianghui Zeng, Binye Li, Shengyan Jian, Liyun Wang
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Journal of Ovarian Research
Subjects:
Polycystic ovarian syndrome
Ovarian granulosa cells
miR-140
RAP2A
AKT
Online Access:https://doi.org/10.1186/s13048-020-0611-4

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