The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival

Background: Survivin is involved in the regulation of cell division and survival, two key processes in cancer. The majority of studies on survivin in colorectal cancer (CRC) have focused on protein expression and less is known about the expression of survivin splicing variants or survivin gene polym...

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Main Authors:	Anna G. Antonacopoulou, Konstantina Floratou, Vasiliki Bravou, Anastasia Kottorou, Fotinos-Ioannis Dimitrakopoulos, Stella Marousi, Michalis Stavropoulos, Agelos K. Koutras, Chrisoula D. Scopa, Haralabos P. Kalofonos
Format:	Article
Language:	English
Published:	Hindawi Limited 2010-01-01
Series:	Analytical Cellular Pathology
Online Access:	http://dx.doi.org/10.3233/ACP-CLO-2010-0537

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spelling	doaj-016a4c6664bd4f1b95e555abacca12b22021-07-02T04:13:42ZengHindawi LimitedAnalytical Cellular Pathology2210-71772210-71852010-01-01335-617718910.3233/ACP-CLO-2010-0537The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall SurvivalAnna G. Antonacopoulou0Konstantina Floratou1Vasiliki Bravou2Anastasia Kottorou3Fotinos-Ioannis Dimitrakopoulos4Stella Marousi5Michalis Stavropoulos6Agelos K. Koutras7Chrisoula D. Scopa8Haralabos P. Kalofonos9Molecular Oncology Laboratory, Medical School, University of Patras, Rion, GreeceMolecular Oncology Laboratory, Medical School, University of Patras, Rion, GreeceMolecular Oncology Laboratory, Medical School, University of Patras, Rion, GreeceMolecular Oncology Laboratory, Medical School, University of Patras, Rion, GreeceMolecular Oncology Laboratory, Medical School, University of Patras, Rion, GreeceMolecular Oncology Laboratory, Medical School, University of Patras, Rion, GreeceDepartment of Surgery, Medical School, University of Patras, Rion, GreeceMolecular Oncology Laboratory, Medical School, University of Patras, Rion, GreeceDepartment of Pathology, Medical School, University of Patras, Rion, GreeceMolecular Oncology Laboratory, Medical School, University of Patras, Rion, GreeceBackground: Survivin is involved in the regulation of cell division and survival, two key processes in cancer. The majority of studies on survivin in colorectal cancer (CRC) have focused on protein expression and less is known about the expression of survivin splicing variants or survivin gene polymorphisms in CRC. In the present study, the mRNA levels of the five known isoforms of survivin as well as survivin protein were assessed in matched normal and neoplastic colorectal tissue. Moreover, the 9386C/T and −31G/C polymorphisms were investigated.http://dx.doi.org/10.3233/ACP-CLO-2010-0537
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Anna G. Antonacopoulou Konstantina Floratou Vasiliki Bravou Anastasia Kottorou Fotinos-Ioannis Dimitrakopoulos Stella Marousi Michalis Stavropoulos Agelos K. Koutras Chrisoula D. Scopa Haralabos P. Kalofonos
spellingShingle	Anna G. Antonacopoulou Konstantina Floratou Vasiliki Bravou Anastasia Kottorou Fotinos-Ioannis Dimitrakopoulos Stella Marousi Michalis Stavropoulos Agelos K. Koutras Chrisoula D. Scopa Haralabos P. Kalofonos The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival Analytical Cellular Pathology
author_facet	Anna G. Antonacopoulou Konstantina Floratou Vasiliki Bravou Anastasia Kottorou Fotinos-Ioannis Dimitrakopoulos Stella Marousi Michalis Stavropoulos Agelos K. Koutras Chrisoula D. Scopa Haralabos P. Kalofonos
author_sort	Anna G. Antonacopoulou
title	The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival
title_short	The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival
title_full	The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival
title_fullStr	The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival
title_full_unstemmed	The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival
title_sort	survivin −31 snp in human colorectal cancer correlates with survivin splice variant expression and improved overall survival
publisher	Hindawi Limited
series	Analytical Cellular Pathology
issn	2210-7177 2210-7185
publishDate	2010-01-01
description	Background: Survivin is involved in the regulation of cell division and survival, two key processes in cancer. The majority of studies on survivin in colorectal cancer (CRC) have focused on protein expression and less is known about the expression of survivin splicing variants or survivin gene polymorphisms in CRC. In the present study, the mRNA levels of the five known isoforms of survivin as well as survivin protein were assessed in matched normal and neoplastic colorectal tissue. Moreover, the 9386C/T and −31G/C polymorphisms were investigated.
url	http://dx.doi.org/10.3233/ACP-CLO-2010-0537
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The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival

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