Circulating oxidized LDL forms complexes with β2-glycoprotein I: implication as an atherogenic autoantigen

Circulating oxidized LDL forms complexes with β2-glycoprotein I: implication as an atherogenic autoantigen

β2-glycoprotein I (β2-GPI) is a major antigen for antiphospholipid antibodies (Abs, aPL) present in patients with antiphospholipid syndrome (APS). We recently reported (J. Lipid Res., 42: 697, 2001; J. Lipid Res., 43: 1486, 2002) that β2-GPI specifically binds to Cu2+-oxidized LDL (oxLDL) and that t...

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Bibliographic Details
Main Authors: Kazuko Kobayashi, Makoto Kishi, Tatsuya Atsumi, Maria L. Bertolaccini, Hirofumi Makino, Nobuo Sakairi, Itaru Yamamoto, Tatsuji Yasuda, Munther A. Khamashta, Graham R.V. Hughes, Takao Koike, Dennis R. Voelker, Eiji Matsuura
Format: Article
Language:English
Published: Elsevier 2003-04-01
Series:Journal of Lipid Research
Subjects:
antiphospholipid syndrome
arterial thrombosis
autoantibody
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520311615

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