The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-β Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Through JAK1

The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-β Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Through JAK1

Although mesenchymal stromal cells (MSCs) are among the most promising cell sources for cell-based therapies and regenerative medicine, the decline in their function with age due to cellular senescence limits their therapeutic applications. Unveiling the underlying mechanism of MSC senescence is the...

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Bibliographic Details
Main Authors: Hyang Ju Lee, Bongkun Choi, Yongsub Kim, Sang Eun Lee, Hye Jin Jin, Hee-Seop Lee, Eun-Ju Chang, Seong Who Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
senescence
mesenchymal stromal cell (MSC)
Toll-like receptor 3 (TLR3)
Janus kinase 1 (JAK1)
interferon-β (IFN-β)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01659/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01659/full

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