A Cell-Signaling Network Temporally Resolves Specific versus Promiscuous Phosphorylation

A Cell-Signaling Network Temporally Resolves Specific versus Promiscuous Phosphorylation

If specific and functional kinase- or phosphatase-substrate interactions are optimized for binding compared to promiscuous interactions, then changes in phosphorylation should occur faster on functional versus promiscuous substrates. To test this hypothesis, we designed a high temporal resolution gl...

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Bibliographic Details
Main Authors:	Evgeny Kanshin, Louis-Philippe Bergeron-Sandoval, S. Sinan Isik, Pierre Thibault, Stephen W. Michnick
Format:	Article
Language:	English
Published:	Elsevier 2015-02-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124715000777

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