Carbon monoxide induced PPARγ SUMOylation and UCP2 block inflammatory gene expression in macrophages.

Carbon monoxide induced PPARγ SUMOylation and UCP2 block inflammatory gene expression in macrophages.

Carbon monoxide (CO) dampens pro-inflammatory responses in a peroxisome proliferator-activated receptor-γ (PPARγ) and p38 mitogen-activated protein kinase (MAPK) dependent manner. Previously, we demonstrated that CO inhibits lipopolysaccharide (LPS)-induced expression of the proinflammatory early gr...

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Bibliographic Details
Main Authors: Arvand Haschemi, Beek Yoke Chin, Markus Jeitler, Harald Esterbauer, Oswald Wagner, Martin Bilban, Leo E Otterbein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3201958?pdf=render

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