Use of a bacteriophage lysin to identify a novel target for antimicrobial development.

Use of a bacteriophage lysin to identify a novel target for antimicrobial development.

We identified an essential cell wall biosynthetic enzyme in Bacillus anthracis and an inhibitor thereof to which the organism did not spontaneously evolve measurable resistance. This work is based on the exquisite binding specificity of bacteriophage-encoded cell wall-hydrolytic lysins, which have e...

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Bibliographic Details
Main Authors: Raymond Schuch, Adam J Pelzek, Assaf Raz, Chad W Euler, Patricia A Ryan, Benjamin Y Winer, Andrew Farnsworth, Shyam S Bhaskaran, C Erec Stebbins, Yong Xu, Adrienne Clifford, David J Bearss, Hariprasad Vankayalapati, Allan R Goldberg, Vincent A Fischetti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3622686?pdf=render

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http://europepmc.org/articles/PMC3622686?pdf=render

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