Efficacy and safety of Naoxintong capsule for treating chronic stable angina: study protocol for a randomized controlled trial
Abstract Background Cardiovascular disease is the leading cause of mortality and morbidity worldwide, Chronic stable angina (CSA) is the main symptom of myocardial ischemia, causes increased risk of major cardiovascular events such as sudden cardiac death and myocardial infarction. Naoxintong (NXT)...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2021-05-01
|
Series: | Trials |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13063-021-05264-y |
id |
doaj-014b39b3275e4ee9ac762c5158d544b8 |
---|---|
record_format |
Article |
spelling |
doaj-014b39b3275e4ee9ac762c5158d544b82021-05-11T14:55:46ZengBMCTrials1745-62152021-05-012211810.1186/s13063-021-05264-yEfficacy and safety of Naoxintong capsule for treating chronic stable angina: study protocol for a randomized controlled trialGao Huanjia0Cai Hairong1Zhuang Jieqin2Dai Xingzhen3Fu Xue4Zhang Weizhang5Chen Bojun6The Second Clinical College of Guangzhou University of Chinese MedicineThe Second Clinical College of Guangzhou University of Chinese MedicineThe Second Affiliated Hospital of Guangzhou University of Traditional Chinese MedicineThe Second Affiliated Hospital of Guangzhou University of Traditional Chinese MedicineThe Second Affiliated Hospital of Guangzhou University of Traditional Chinese MedicineThe Second Affiliated Hospital of Guangzhou University of Traditional Chinese MedicineThe Second Affiliated Hospital of Guangzhou University of Traditional Chinese MedicineAbstract Background Cardiovascular disease is the leading cause of mortality and morbidity worldwide, Chronic stable angina (CSA) is the main symptom of myocardial ischemia, causes increased risk of major cardiovascular events such as sudden cardiac death and myocardial infarction. Naoxintong (NXT) capsule is a classical traditional Chinese medication used to treat CSA, however, few evidence to support the wide utility of NXT capsule for the treatment of CSA. We design this study to evaluate the efficacy and safety of NXT capsule versus placebo in patients with CSA. Methods/design This is a multicenter, randomized, double-blind, placebo-controlled clinical trial. A total of 260 eligible participants will be enrolled. The participants will be randomized assigned in an equal ratio to groups receiving either NXT or placebo for 12 weeks. After a 2-week run-in period, they will receive either NXT or placebo (3 pills, 3 times daily) for 12 weeks. The primary outcome is therapeutic efficacy. Secondary outcome measures include the quantitative score of TCM syndromes, severity grading of angina pectoris, the number of angina pectoris per week, nitroglycerin dosage, score of Seattle angina scale, serum homocysteine, and incidence of cardiovascular events. Safety outcomes and adverse events will be monitored throughout the trial. Discussion We designed this study in accordance with principles and regulations issued by the China Food and Drug Administration (CFDA). The results will provide clinical evidence of the efficacy and safety of NXT Capsule in the treatment of CSA. Trial registration Chinese Clinical Trial Registry ChiCTR2100044563 . Registered on 24 March 2020.https://doi.org/10.1186/s13063-021-05264-yChronic stable anginaNaoxintong capsuleTraditional Chinese medicineRandomized controlled trial |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gao Huanjia Cai Hairong Zhuang Jieqin Dai Xingzhen Fu Xue Zhang Weizhang Chen Bojun |
spellingShingle |
Gao Huanjia Cai Hairong Zhuang Jieqin Dai Xingzhen Fu Xue Zhang Weizhang Chen Bojun Efficacy and safety of Naoxintong capsule for treating chronic stable angina: study protocol for a randomized controlled trial Trials Chronic stable angina Naoxintong capsule Traditional Chinese medicine Randomized controlled trial |
author_facet |
Gao Huanjia Cai Hairong Zhuang Jieqin Dai Xingzhen Fu Xue Zhang Weizhang Chen Bojun |
author_sort |
Gao Huanjia |
title |
Efficacy and safety of Naoxintong capsule for treating chronic stable angina: study protocol for a randomized controlled trial |
title_short |
Efficacy and safety of Naoxintong capsule for treating chronic stable angina: study protocol for a randomized controlled trial |
title_full |
Efficacy and safety of Naoxintong capsule for treating chronic stable angina: study protocol for a randomized controlled trial |
title_fullStr |
Efficacy and safety of Naoxintong capsule for treating chronic stable angina: study protocol for a randomized controlled trial |
title_full_unstemmed |
Efficacy and safety of Naoxintong capsule for treating chronic stable angina: study protocol for a randomized controlled trial |
title_sort |
efficacy and safety of naoxintong capsule for treating chronic stable angina: study protocol for a randomized controlled trial |
publisher |
BMC |
series |
Trials |
issn |
1745-6215 |
publishDate |
2021-05-01 |
description |
Abstract Background Cardiovascular disease is the leading cause of mortality and morbidity worldwide, Chronic stable angina (CSA) is the main symptom of myocardial ischemia, causes increased risk of major cardiovascular events such as sudden cardiac death and myocardial infarction. Naoxintong (NXT) capsule is a classical traditional Chinese medication used to treat CSA, however, few evidence to support the wide utility of NXT capsule for the treatment of CSA. We design this study to evaluate the efficacy and safety of NXT capsule versus placebo in patients with CSA. Methods/design This is a multicenter, randomized, double-blind, placebo-controlled clinical trial. A total of 260 eligible participants will be enrolled. The participants will be randomized assigned in an equal ratio to groups receiving either NXT or placebo for 12 weeks. After a 2-week run-in period, they will receive either NXT or placebo (3 pills, 3 times daily) for 12 weeks. The primary outcome is therapeutic efficacy. Secondary outcome measures include the quantitative score of TCM syndromes, severity grading of angina pectoris, the number of angina pectoris per week, nitroglycerin dosage, score of Seattle angina scale, serum homocysteine, and incidence of cardiovascular events. Safety outcomes and adverse events will be monitored throughout the trial. Discussion We designed this study in accordance with principles and regulations issued by the China Food and Drug Administration (CFDA). The results will provide clinical evidence of the efficacy and safety of NXT Capsule in the treatment of CSA. Trial registration Chinese Clinical Trial Registry ChiCTR2100044563 . Registered on 24 March 2020. |
topic |
Chronic stable angina Naoxintong capsule Traditional Chinese medicine Randomized controlled trial |
url |
https://doi.org/10.1186/s13063-021-05264-y |
work_keys_str_mv |
AT gaohuanjia efficacyandsafetyofnaoxintongcapsulefortreatingchronicstableanginastudyprotocolforarandomizedcontrolledtrial AT caihairong efficacyandsafetyofnaoxintongcapsulefortreatingchronicstableanginastudyprotocolforarandomizedcontrolledtrial AT zhuangjieqin efficacyandsafetyofnaoxintongcapsulefortreatingchronicstableanginastudyprotocolforarandomizedcontrolledtrial AT daixingzhen efficacyandsafetyofnaoxintongcapsulefortreatingchronicstableanginastudyprotocolforarandomizedcontrolledtrial AT fuxue efficacyandsafetyofnaoxintongcapsulefortreatingchronicstableanginastudyprotocolforarandomizedcontrolledtrial AT zhangweizhang efficacyandsafetyofnaoxintongcapsulefortreatingchronicstableanginastudyprotocolforarandomizedcontrolledtrial AT chenbojun efficacyandsafetyofnaoxintongcapsulefortreatingchronicstableanginastudyprotocolforarandomizedcontrolledtrial |
_version_ |
1721443825977655296 |