Methylation of the claudin 1 promoter is associated with loss of expression in estrogen receptor positive breast cancer.

Methylation of the claudin 1 promoter is associated with loss of expression in estrogen receptor positive breast cancer.

Downregulation of the tight junction protein claudin 1 is a frequent event in breast cancer and is associated with recurrence, metastasis, and reduced survival, suggesting a tumor suppressor role for this protein. Tumor suppressor genes are often epigenetically silenced in cancer. Downregulation of...

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Bibliographic Details
Main Authors: Francescopaolo Di Cello, Leslie Cope, Huili Li, Jana Jeschke, Wei Wang, Stephen B Baylin, Cynthia A Zahnow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3701071?pdf=render

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