Spatial control of bone formation using a porous polymer scaffold co-delivering anabolic rhBMP-2 and anti-resorptive agents

Spatial control of bone formation using a porous polymer scaffold co-delivering anabolic rhBMP-2 and anti-resorptive agents

Current clinical delivery of recombinant human bone morphogenetic proteins (rhBMPs) utilises freeze-dried collagen. Despite effective new bone generation, rhBMP via collagen can be limited by significant complications due to inflammation and uncontrolled bone formation. This study aimed to produce a...

Full description

Bibliographic Details
Main Authors:	NYC Yu, M Gdalevitch, CM Murphy, K Mikulec, L Peacock, J Fitzpatrick, LC Cantrill, AJ Ruys, JJ Cooper-White, DG Little, A Schindeler
Format:	Article
Language:	English
Published:	AO Research Institute Davos 2014-01-01
Series:	European Cells & Materials
Online Access:	http://www.ecmjournal.org/papers/vol027/pdf/v027a08.pdf

Similar Items

Modulation of anabolic and catabolic responses via a porous polymer scaffold manufactured using thermally induced phase separation
by: A Schindeler, et al.
Published: (2013-02-01)

Vergleich der Osteoinduktivität von rhBMP-2 und rhBMP-2-Mutanten : eine Untersuchung im heterotopen Rattenmodell
by: Emmert, Janne
Published: (2004)

Combined Mesenchymal Stem Cell Sheets and rhBMP-2-Releasing Calcium Sulfate–rhBMP-2 Scaffolds for Segmental Bone Tissue Engineering
by: Yiying Qi, et al.
Published: (2012-04-01)

Vertical bone regeneration using rhBMP-2 and VEGF
by: Lara Schorn, et al.
Published: (2017-06-01)

Unveiling novel genes upregulated by both rhBMP2 and rhBMP7 during early osteoblastic transdifferentiation of C2C12 cells
by: Sogayar Mari C, et al.
Published: (2011-09-01)

An in vivo Comparison Study Between Strontium Nanoparticles and rhBMP2
by: Giulia Montagna, et al.
Published: (2020-06-01)

Preparation and Characterization of Coaxial Electrospinning rhBMP2-Loaded Nanofiber Membranes
by: He Zhao, et al.
Published: (2019-01-01)

Bone regeneration in ceramic scaffolds with variable concentrations of PDRN and rhBMP-2
by: Ho-Kyung Lim, et al.
Published: (2021-06-01)

rhBMP in lumber fusion for lumbar spondylolisthesis: A systematic review and meta-analysis
by: Peng-Fei Han, et al.
Published: (2019-02-01)

Mesenchymal stem cells with rhBMP-2 inhibits the growth of canine osteosarcoma cells
by: Grassi Rici Rose, et al.
Published: (2012-02-01)

Effect of rhBMP-2 Immobilized Anorganic Bovine Bone Matrix on Bone Regeneration
by: Jung-Bo Huh, et al.
Published: (2015-07-01)

Effect of rhBMP-7 dosing during distraction osteogenesis in wild type mice
by: Izadpanah, Ali
Published: (2011)

Cell saver filtering of extravasated rhBMP-2 after degenerative scoliosis reconstruction
by: Gabriel Liu, MBBCh, MSc, FRCS, FAMS (Orth), et al.
Published: (2015-06-01)

Effects of Immobilizations of rhBMP-2 and/or rhPDGF-BB on Titanium Implant Surfaces on Osseointegration and Bone Regeneration
by: So-Hyoun Lee, et al.
Published: (2017-12-01)

In vivo local co-delivery of recombinant human bone morphogenetic protein-7 and pamidronate via poly-D, L-lactic acid
by: NYC Yu, et al.
Published: (2010-12-01)

Nanostructured Carbonated Hydroxyapatite Associated to rhBMP-2 Improves Bone Repair in Rat Calvaria
by: Thiago Schneider Werner Vianna, et al.
Published: (2020-12-01)

Effectiveness of morphogenetic protein rhBMP-2 use in atypical third mandibular molars extraction.
by: O. O. Gudaryan, et al.
Published: (2020-07-01)

Anisotropic Cryostructured Collagen Scaffolds for Efficient Delivery of RhBMP–2 and Enhanced Bone Regeneration
by: Kai Stuckensen, et al.
Published: (2019-09-01)

Off-label use of rhBMP-2 as bone regeneration strategies in mandibular ameloblastoma unicystic
by: Henrique Celestino Lima e Silva, et al.

Effect of Different rhBMP-2 and TG-VEGF Ratios on the Formation of Heterotopic Bone and Neovessels
by: Wei Xin Cai, et al.
Published: (2014-01-01)

Collagen sponge and rhBMP-2 improve socket healing in rats treated with zoledronic acid
by: Ji-Su OH, et al.
Published: (2017-12-01)

Development of an Aqueous Suspension of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2)
by: Schwartz, Daniel
Published: (2005)

The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillofacial trauma
by: A.S. Herford
Published: (2017-02-01)

Bone marrow concentrate promotes bone regeneration with a suboptimal-dose of rhBMP-2.
by: Kazuhiro Egashira, et al.
Published: (2018-01-01)

Effect of guided bone regeneration with rhBMP-2 on bone quality surrounding dental implants
by: Johnson, Trenton
Published: (2018)

Bone induction and defect repair by true bone ceramics incorporated with rhBMP-2 and Sr
by: Chunli Zhang, et al.
Published: (2021-08-01)

Effects of rhBMP-2 Loaded Titanium Reinforced Collagen Membranes on Horizontal Bone Augmentation in Dogs
by: Ki-Sun Lee, et al.
Published: (2017-01-01)

Reduced Burst Release of Bioactive rhBMP-2 from a Three-phase Composite Scaffold
by: Grant, David William
Published: (2010)

Reduced Burst Release of Bioactive rhBMP-2 from a Three-phase Composite Scaffold
by: Grant, David William
Published: (2010)

Evalution of Synthetic Polymers-Gelatin Composite Scaffold As rhBMP-2 Delivery System in Bone Regeneration
by: CHIN-LUNG, LIU, et al.
Published: (2006)

Aligned electrospun cellulose scaffolds coated with rhBMP-2 for both in vitro and in vivo bone tissue engineering
by: Zhang, X., et al.
Published: (2019)

Synergistic Effect of rhBMP-2 Protein and Nanotextured Titanium Alloy Surface to Improve Osteogenic Implant Properties
by: Andrea Mesa-Restrepo, et al.
Published: (2021-03-01)

Expression of recombinant human bone morphogenetic protein 2 (rhBMP2) in tobacco transgenic hairy roots
by: Balal Dehghani, et al.
Published: (2018-06-01)

Corrigendum to “Effects of rhBMP-2 Loaded Titanium Reinforced Collagen Membranes on Horizontal Bone Augmentation in Dogs”
by: Ki-Sun Lee, et al.
Published: (2018-01-01)

Modulation effect of rhBMP2 on osteogenic activity in human periodontal ligament fibroblasts and osteoblast cell lines
by: Tai-I Li, et al.
Published: (2005)

A BIORELEVANT IN VITRO MODEL TO CHARACTERIZE IN VIVO RELEASE OF BONE MORPHOGENETIC PROTEIN-2 (rhBMP-2)
by: BISWAS, DEBLINA
Published: (2017)

Análise dos genes diferencialmente expressos durante a osteodiferenciação induzida por proteínas morfogenéticas de osso (BMP2 e BMP7) em células C2C12 e super-expressão de rhBMP2 e rhBMP7 em células de mamíferos
by: Juan Carlos Bustos Valenzuela
Published: (2008)

Análise dos genes diferencialmente expressos durante a osteodiferenciação induzida por proteínas morfogenéticas de osso (BMP2 e BMP7) em células C2C12 e super-expressão de rhBMP2 e rhBMP7 em células de mamíferos
by: Valenzuela, Juan Carlos Bustos
Published: (2008)

Knochenregeneration mit rhBMP-2 und unterschiedlichen Trägermaterialien - Biomechanische, fluoreszenzmorphometrische und radiomorphometrische Untersuchungen im Rattenmodell
by: Liebl, Oliver
Published: (2004)

Radiographic Assessment of Bone Formation Using rhBMP2 at Maxillary Periapical Surgical Defects: A Case Series
by: M.SIVA KUMAR, et al.
Published: (2016-04-01)