Antibiotic Resistant <i>Pseudomonas</i> Spp. Spoilers in Fresh Dairy Products: An Underestimated Risk and the Control Strategies

Microbial multidrug resistance (MDR) is a growing threat to public health mostly because it makes the fight against microorganisms that cause lethal infections ever less effective. Thus, the surveillance on MDR microorganisms has recently been strengthened, taking into account the control of antibio...

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Main Authors: Laura Quintieri, Francesca Fanelli, Leonardo Caputo
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Foods
Subjects:
Online Access:https://www.mdpi.com/2304-8158/8/9/372
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spelling doaj-012b3346156a4d2f8667250b2260992e2020-11-24T22:13:35ZengMDPI AGFoods2304-81582019-09-018937210.3390/foods8090372foods8090372Antibiotic Resistant <i>Pseudomonas</i> Spp. Spoilers in Fresh Dairy Products: An Underestimated Risk and the Control StrategiesLaura Quintieri0Francesca Fanelli1Leonardo Caputo2Institute of Sciences of Food Production, National Research Council of Italy, Via G. Amendola 122/O, 70126 Bari, ItalyInstitute of Sciences of Food Production, National Research Council of Italy, Via G. Amendola 122/O, 70126 Bari, ItalyInstitute of Sciences of Food Production, National Research Council of Italy, Via G. Amendola 122/O, 70126 Bari, ItalyMicrobial multidrug resistance (MDR) is a growing threat to public health mostly because it makes the fight against microorganisms that cause lethal infections ever less effective. Thus, the surveillance on MDR microorganisms has recently been strengthened, taking into account the control of antibiotic abuse as well as the mechanisms underlying the transfer of antibiotic genes (ARGs) among microbiota naturally occurring in the environment. Indeed, ARGs are not only confined to pathogenic bacteria, whose diffusion in the clinical field has aroused serious concerns, but are widespread in saprophytic bacterial communities such as those dominating the food industry. In particular, fresh dairy products can be considered a reservoir of <i>Pseudomonas</i> spp. resistome, potentially transmittable to consumers. Milk and fresh dairy cheeses products represent one of a few &#8220;hubs&#8221; where commensal or opportunistic pseudomonads frequently cohabit together with food microbiota and hazard pathogens even across their manufacturing processes. <i>Pseudomonas</i> spp., widely studied for food spoilage effects, are instead underestimated for their possible impact on human health. Recent evidences have highlighted that non-pathogenic pseudomonads strains (<i>P. fluorescens, P. putida</i>) are associated with some human diseases, but are still poorly considered in comparison to the pathogen <i>P. aeruginosa.</i> In addition, the presence of ARGs, that can be acquired and transmitted by horizontal genetic transfer, further increases their risk and the need to be deeper investigated. Therefore, this review, starting from the general aspects related to the physiological traits of these spoilage microorganisms from fresh dairy products, aims to shed light on the resistome of cheese-related pseudomonads and their genomic background, current methods and advances in the prediction tools for MDR detection based on genomic sequences, possible implications for human health, and the affordable strategies to counteract MDR spread.https://www.mdpi.com/2304-8158/8/9/372antibiotic resistancedairy productspseudomonadsspoilagebiofilmquorum sensinggenomicscontrol strategies
collection DOAJ
language English
format Article
sources DOAJ
author Laura Quintieri
Francesca Fanelli
Leonardo Caputo
spellingShingle Laura Quintieri
Francesca Fanelli
Leonardo Caputo
Antibiotic Resistant <i>Pseudomonas</i> Spp. Spoilers in Fresh Dairy Products: An Underestimated Risk and the Control Strategies
Foods
antibiotic resistance
dairy products
pseudomonads
spoilage
biofilm
quorum sensing
genomics
control strategies
author_facet Laura Quintieri
Francesca Fanelli
Leonardo Caputo
author_sort Laura Quintieri
title Antibiotic Resistant <i>Pseudomonas</i> Spp. Spoilers in Fresh Dairy Products: An Underestimated Risk and the Control Strategies
title_short Antibiotic Resistant <i>Pseudomonas</i> Spp. Spoilers in Fresh Dairy Products: An Underestimated Risk and the Control Strategies
title_full Antibiotic Resistant <i>Pseudomonas</i> Spp. Spoilers in Fresh Dairy Products: An Underestimated Risk and the Control Strategies
title_fullStr Antibiotic Resistant <i>Pseudomonas</i> Spp. Spoilers in Fresh Dairy Products: An Underestimated Risk and the Control Strategies
title_full_unstemmed Antibiotic Resistant <i>Pseudomonas</i> Spp. Spoilers in Fresh Dairy Products: An Underestimated Risk and the Control Strategies
title_sort antibiotic resistant <i>pseudomonas</i> spp. spoilers in fresh dairy products: an underestimated risk and the control strategies
publisher MDPI AG
series Foods
issn 2304-8158
publishDate 2019-09-01
description Microbial multidrug resistance (MDR) is a growing threat to public health mostly because it makes the fight against microorganisms that cause lethal infections ever less effective. Thus, the surveillance on MDR microorganisms has recently been strengthened, taking into account the control of antibiotic abuse as well as the mechanisms underlying the transfer of antibiotic genes (ARGs) among microbiota naturally occurring in the environment. Indeed, ARGs are not only confined to pathogenic bacteria, whose diffusion in the clinical field has aroused serious concerns, but are widespread in saprophytic bacterial communities such as those dominating the food industry. In particular, fresh dairy products can be considered a reservoir of <i>Pseudomonas</i> spp. resistome, potentially transmittable to consumers. Milk and fresh dairy cheeses products represent one of a few &#8220;hubs&#8221; where commensal or opportunistic pseudomonads frequently cohabit together with food microbiota and hazard pathogens even across their manufacturing processes. <i>Pseudomonas</i> spp., widely studied for food spoilage effects, are instead underestimated for their possible impact on human health. Recent evidences have highlighted that non-pathogenic pseudomonads strains (<i>P. fluorescens, P. putida</i>) are associated with some human diseases, but are still poorly considered in comparison to the pathogen <i>P. aeruginosa.</i> In addition, the presence of ARGs, that can be acquired and transmitted by horizontal genetic transfer, further increases their risk and the need to be deeper investigated. Therefore, this review, starting from the general aspects related to the physiological traits of these spoilage microorganisms from fresh dairy products, aims to shed light on the resistome of cheese-related pseudomonads and their genomic background, current methods and advances in the prediction tools for MDR detection based on genomic sequences, possible implications for human health, and the affordable strategies to counteract MDR spread.
topic antibiotic resistance
dairy products
pseudomonads
spoilage
biofilm
quorum sensing
genomics
control strategies
url https://www.mdpi.com/2304-8158/8/9/372
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AT leonardocaputo antibioticresistantipseudomonasisppspoilersinfreshdairyproductsanunderestimatedriskandthecontrolstrategies
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