Redox-Responsive Disulfide Bond-Bridged mPEG-PBLA Prodrug Micelles for Enhanced Paclitaxel Biosafety and Antitumor Efficacy

Redox-Responsive Disulfide Bond-Bridged mPEG-PBLA Prodrug Micelles for Enhanced Paclitaxel Biosafety and Antitumor Efficacy

The toxicity and side effects of traditional chemotherapeutic drugs are the main causes of chemotherapy failure. To improve the specificity and selectivity of chemotherapeutic drugs for tumor cells, a novel redox-sensitive polymer prodrug, polyethylene glycol-poly (β-benzyl-L-aspartate) (PEG-PBLA)-S...

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Bibliographic Details
Main Authors: Sheng Chang, Yanfei Wang, Tianyi Zhang, Xiaohui Pu, Lanlan Zong, Heyun Zhu, Luling Zhao, Bo Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Oncology
Subjects:
redox responsion
mPEG-PBLA
prodrug micelles
paclitaxel
antitumor efficacy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00823/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00823/full

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