Mitochondrial Malfunctioning, Proteasome Arrest and Apoptosis in Cancer Cells by Focused Intracellular Generation of Oxygen Radicals

Mitochondrial Malfunctioning, Proteasome Arrest and Apoptosis in Cancer Cells by Focused Intracellular Generation of Oxygen Radicals

Photofrin/photodynamic therapy (PDT) at sub-lethal doses induced a transient stall in proteasome activity in surviving A549 (p53+/+) and H1299 (p53−/−) cells as indicated by the time-dependent decline/recovery of chymotrypsin-like activity. Indeed, within 3 h of incubation, Photofrin invaded the cyt...

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Bibliographic Details
Main Authors: Ilaria Postiglione, Angela Chiaviello, Federica Barra, Emanuela Roscetto, Amata A. Soriano, Maria Rosaria Catania, Giuseppe Palumbo, Giovanna Maria Pierantoni
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:International Journal of Molecular Sciences
Subjects:
photodynamic therapy
Photofrin
Bortezomib
combination therapy
proteasome
Online Access:http://www.mdpi.com/1422-0067/16/9/20375

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