Desenvolvimento e validação de método analítico para a determinação de sulfassalazina em suspensão oral: comparação do método espectrofotométrico e de cromatografia líquida de alta eficiência (CLAE)

Desenvolvimento e validação de método analítico para a determinação de sulfassalazina em suspensão oral: comparação do método espectrofotométrico e de cromatografia líquida de alta eficiência (CLAE)

Sulfasalazine is a prodrug used in the treatment of the Chron's disease and rheumatoid arthritis. Two analytical methods for analysis of sulfasalazine in oral suspension were validated using Spectrophotometric and HPLC. There is not any pharmacopoeic method to assay sulfasalazine in oral suspen...

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Bibliographic Details
Main Authors: Mayre Aparecida Borges da Costa, Eduardo Ricci-Júnior, Elisabete Pereira dos Santos, Claudia Regina Elias Mansur, Vânia Emerich Bucco de Campos
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2012-01-01
Series:Química Nova
Subjects:
sulfasalazine
oral suspension
analytical method
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000400028&lng=en&tlng=en
Description
Summary:Sulfasalazine is a prodrug used in the treatment of the Chron's disease and rheumatoid arthritis. Two analytical methods for analysis of sulfasalazine in oral suspension were validated using Spectrophotometric and HPLC. There is not any pharmacopoeic method to assay sulfasalazine in oral suspension. The methods are insurance and fast execution for the quality control. Both, suspension and tablets 500 mg (Azulfin®) had been analyzed by methods using UV/VIS and HPLC and the results were satisfactory.
ISSN:1678-7064

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