Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium

Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium

Summary: DNA damage activates checkpoints that limit the replicative potential of stem cells, including differentiation. These checkpoints protect against cancer development but also promote tissue aging. Because mice lacking Slug/Snai2 exhibit limited stem cell activity, including luminobasal diffe...

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Bibliographic Details
Main Authors: Kayla M. Gross, Wenhui Zhou, Jerrica L. Breindel, Jian Ouyang, Dexter X. Jin, Ethan S. Sokol, Piyush B. Gupta, Kathryn Huber, Lee Zou, Charlotte Kuperwasser
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719308162

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http://www.sciencedirect.com/science/article/pii/S2211124719308162

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