Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells

Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells

Cheng et al. provide a detailed characterization of the differentiation of human pluripotent stem cells to valve endothelial cells and their function. Their results show that the valve endothelial-like cells express key markers for valve endothelial cells, exhibiting proliferative and clonogenic pot...

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Main Authors: LinXi Cheng, MingHui Xie, WeiHua Qiao, Yu Song, YanYong Zhang, YingChao Geng, WeiLin Xu, Lin Wang, Zheng Wang, Kai Huang, NianGuo Dong, YuHua Sun
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02571-7
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spelling doaj-00f4479e6cab46848b34a82b21781d662021-09-12T11:12:26ZengNature Publishing GroupCommunications Biology2399-36422021-09-014111510.1038/s42003-021-02571-7Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cellsLinXi Cheng0MingHui Xie1WeiHua Qiao2Yu Song3YanYong Zhang4YingChao Geng5WeiLin Xu6Lin Wang7Zheng Wang8Kai Huang9NianGuo Dong10YuHua Sun11Institute of Hydrobiology, Chinese Academy of SciencesDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyInstitute of Hydrobiology, Chinese Academy of SciencesInstitute of Hydrobiology, Chinese Academy of SciencesWuhan Textile UniversityResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Cardiovascular Internal Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyInstitute of Hydrobiology, Chinese Academy of SciencesCheng et al. provide a detailed characterization of the differentiation of human pluripotent stem cells to valve endothelial cells and their function. Their results show that the valve endothelial-like cells express key markers for valve endothelial cells, exhibiting proliferative and clonogenic potential.https://doi.org/10.1038/s42003-021-02571-7
collection DOAJ
language English
format Article
sources DOAJ
author LinXi Cheng
MingHui Xie
WeiHua Qiao
Yu Song
YanYong Zhang
YingChao Geng
WeiLin Xu
Lin Wang
Zheng Wang
Kai Huang
NianGuo Dong
YuHua Sun
spellingShingle LinXi Cheng
MingHui Xie
WeiHua Qiao
Yu Song
YanYong Zhang
YingChao Geng
WeiLin Xu
Lin Wang
Zheng Wang
Kai Huang
NianGuo Dong
YuHua Sun
Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells
Communications Biology
author_facet LinXi Cheng
MingHui Xie
WeiHua Qiao
Yu Song
YanYong Zhang
YingChao Geng
WeiLin Xu
Lin Wang
Zheng Wang
Kai Huang
NianGuo Dong
YuHua Sun
author_sort LinXi Cheng
title Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells
title_short Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells
title_full Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells
title_fullStr Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells
title_full_unstemmed Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells
title_sort generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-09-01
description Cheng et al. provide a detailed characterization of the differentiation of human pluripotent stem cells to valve endothelial cells and their function. Their results show that the valve endothelial-like cells express key markers for valve endothelial cells, exhibiting proliferative and clonogenic potential.
url https://doi.org/10.1038/s42003-021-02571-7
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