Degenerated human intervertebral discs contain autoantibodies against extracellular matrix proteins

Degenerated human intervertebral discs contain autoantibodies against extracellular matrix proteins

Degeneration of intervertebral discs (IVDs) is associated with back pain and elevated levels of inflammatory cells. It has been hypothesised that discogenic pain is a direct result of vascular and neural ingrowth along annulus fissures, which may expose the avascular nucleus pulposus (NP) to the sys...

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Bibliographic Details
Main Authors: S Capossela, P Schläfli, A Bertolo, T Janner, BM Stadler, T Pötzel, M Baur, JV Stoyanov
Format: Article
Language:English
Published: AO Research Institute Davos 2014-04-01
Series:European Cells & Materials
Subjects:
nucleus pulposus
annulus fibrosus
Intervertebral disc
extracellular matrix
Online Access:http://www.ecmjournal.org/journal/papers/vol027/pdf/v027a18.pdf

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