Development of UHPLC-MS/MS Method for Indirubin-3′-Oxime Derivative as a Novel FLT3 Inhibitor and Pharmacokinetic Study in Rats

Development of UHPLC-MS/MS Method for Indirubin-3′-Oxime Derivative as a Novel FLT3 Inhibitor and Pharmacokinetic Study in Rats

This study aimed to develop and validate a sensitive liquid chromatography-coupled tandem mass spectrometry method for the quantification of LDD-2614, an indirubin derivative and novel FLT3 inhibitor, in rat plasma. In addition, the developed analytical method was applied to observe the pharmacokine...

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Bibliographic Details
Main Authors:	Na Yoon Kim, Yong-Chul Kim, Yoon Gyoon Kim
Format:	Article
Language:	English
Published:	MDPI AG 2020-04-01
Series:	Molecules
Subjects:	LDD-2614 novel FLT3 inhibitor indirubin derivative LC-MS/MS pharmacokinetics
Online Access:	https://www.mdpi.com/1420-3049/25/9/2039

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