TMP21 in Alzheimer’s Disease: Molecular Mechanisms and a Potential Target

Alzheimer’s disease (AD) is the most common form of dementia in the elderly, which is characterized by progressive cognitive impairment. Neuritic plaques, neurofibrillary tangles and neuronal loss are the major neuropathological hallmarks in AD brains. TMP21 is a key molecule for protein trafficking...

Full description

Bibliographic Details
Main Authors:	Kaixin Qiu, Xiaojie Zhang, Shuai Wang, Chunyan Li, Xin Wang, Xuezhi Li, Yili Wu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-07-01
Series:	Frontiers in Cellular Neuroscience
Subjects:	Alzheimer’s disease TMP21 Aβ Tau phosphorylation neuronal loss
Online Access:	https://www.frontiersin.org/article/10.3389/fncel.2019.00328/full

id	doaj-00e7cce10a4340f6a65fbdf7a1cd92d2
record_format	Article
spelling	doaj-00e7cce10a4340f6a65fbdf7a1cd92d22020-11-25T01:57:40ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022019-07-011310.3389/fncel.2019.00328467588TMP21 in Alzheimer’s Disease: Molecular Mechanisms and a Potential TargetKaixin Qiu0Kaixin Qiu1Kaixin Qiu2Xiaojie Zhang3Xiaojie Zhang4Xiaojie Zhang5Shuai Wang6Shuai Wang7Chunyan Li8Chunyan Li9Chunyan Li10Xin Wang11Xin Wang12Xuezhi Li13Xuezhi Li14Yili Wu15Yili Wu16Cheeloo College of Medicine, Shandong University, Jinan, ChinaShandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions, Institute of Mental Health, Jining Medical University, Jining, ChinaShandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jining, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, Changsha, ChinaNational Technology Institute on Mental Disorders, Changsha, ChinaShandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions, Institute of Mental Health, Jining Medical University, Jining, ChinaShandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jining, ChinaCheeloo College of Medicine, Shandong University, Jinan, ChinaShandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions, Institute of Mental Health, Jining Medical University, Jining, ChinaShandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jining, ChinaShandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions, Institute of Mental Health, Jining Medical University, Jining, ChinaShandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jining, ChinaShandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions, Institute of Mental Health, Jining Medical University, Jining, ChinaShandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jining, ChinaShandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions, Institute of Mental Health, Jining Medical University, Jining, ChinaShandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jining, ChinaAlzheimer’s disease (AD) is the most common form of dementia in the elderly, which is characterized by progressive cognitive impairment. Neuritic plaques, neurofibrillary tangles and neuronal loss are the major neuropathological hallmarks in AD brains. TMP21 is a key molecule for protein trafficking in cells. Growing evidence indicates that TMP21 is dysregulated in AD, which plays a pivotal role in neuritic plaque formation. Therefore, we aim to review the dysregulation of TMP21 in AD, the role of TMP21 in neuritic plaque formation and underlying mechanisms. Moreover, the potential role of TMP21 in neurofibrillary tangle formation, synaptic impairment and neuronal loss is discussed. It will provide an outlook into the potential of regulating TMP21 as a therapeutic approach for AD treatment.https://www.frontiersin.org/article/10.3389/fncel.2019.00328/fullAlzheimer’s diseaseTMP21AβTau phosphorylationneuronal loss
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kaixin Qiu Kaixin Qiu Kaixin Qiu Xiaojie Zhang Xiaojie Zhang Xiaojie Zhang Shuai Wang Shuai Wang Chunyan Li Chunyan Li Chunyan Li Xin Wang Xin Wang Xuezhi Li Xuezhi Li Yili Wu Yili Wu
spellingShingle	Kaixin Qiu Kaixin Qiu Kaixin Qiu Xiaojie Zhang Xiaojie Zhang Xiaojie Zhang Shuai Wang Shuai Wang Chunyan Li Chunyan Li Chunyan Li Xin Wang Xin Wang Xuezhi Li Xuezhi Li Yili Wu Yili Wu TMP21 in Alzheimer’s Disease: Molecular Mechanisms and a Potential Target Frontiers in Cellular Neuroscience Alzheimer’s disease TMP21 Aβ Tau phosphorylation neuronal loss
author_facet	Kaixin Qiu Kaixin Qiu Kaixin Qiu Xiaojie Zhang Xiaojie Zhang Xiaojie Zhang Shuai Wang Shuai Wang Chunyan Li Chunyan Li Chunyan Li Xin Wang Xin Wang Xuezhi Li Xuezhi Li Yili Wu Yili Wu
author_sort	Kaixin Qiu
title	TMP21 in Alzheimer’s Disease: Molecular Mechanisms and a Potential Target
title_short	TMP21 in Alzheimer’s Disease: Molecular Mechanisms and a Potential Target
title_full	TMP21 in Alzheimer’s Disease: Molecular Mechanisms and a Potential Target
title_fullStr	TMP21 in Alzheimer’s Disease: Molecular Mechanisms and a Potential Target
title_full_unstemmed	TMP21 in Alzheimer’s Disease: Molecular Mechanisms and a Potential Target
title_sort	tmp21 in alzheimer’s disease: molecular mechanisms and a potential target
publisher	Frontiers Media S.A.
series	Frontiers in Cellular Neuroscience
issn	1662-5102
publishDate	2019-07-01
description	Alzheimer’s disease (AD) is the most common form of dementia in the elderly, which is characterized by progressive cognitive impairment. Neuritic plaques, neurofibrillary tangles and neuronal loss are the major neuropathological hallmarks in AD brains. TMP21 is a key molecule for protein trafficking in cells. Growing evidence indicates that TMP21 is dysregulated in AD, which plays a pivotal role in neuritic plaque formation. Therefore, we aim to review the dysregulation of TMP21 in AD, the role of TMP21 in neuritic plaque formation and underlying mechanisms. Moreover, the potential role of TMP21 in neurofibrillary tangle formation, synaptic impairment and neuronal loss is discussed. It will provide an outlook into the potential of regulating TMP21 as a therapeutic approach for AD treatment.
topic	Alzheimer’s disease TMP21 Aβ Tau phosphorylation neuronal loss
url	https://www.frontiersin.org/article/10.3389/fncel.2019.00328/full
work_keys_str_mv	AT kaixinqiu tmp21inalzheimersdiseasemolecularmechanismsandapotentialtarget AT kaixinqiu tmp21inalzheimersdiseasemolecularmechanismsandapotentialtarget AT kaixinqiu tmp21inalzheimersdiseasemolecularmechanismsandapotentialtarget AT xiaojiezhang tmp21inalzheimersdiseasemolecularmechanismsandapotentialtarget AT xiaojiezhang tmp21inalzheimersdiseasemolecularmechanismsandapotentialtarget AT xiaojiezhang tmp21inalzheimersdiseasemolecularmechanismsandapotentialtarget AT shuaiwang tmp21inalzheimersdiseasemolecularmechanismsandapotentialtarget AT shuaiwang tmp21inalzheimersdiseasemolecularmechanismsandapotentialtarget AT chunyanli tmp21inalzheimersdiseasemolecularmechanismsandapotentialtarget AT chunyanli tmp21inalzheimersdiseasemolecularmechanismsandapotentialtarget AT chunyanli tmp21inalzheimersdiseasemolecularmechanismsandapotentialtarget AT xinwang tmp21inalzheimersdiseasemolecularmechanismsandapotentialtarget AT xinwang tmp21inalzheimersdiseasemolecularmechanismsandapotentialtarget AT xuezhili tmp21inalzheimersdiseasemolecularmechanismsandapotentialtarget AT xuezhili tmp21inalzheimersdiseasemolecularmechanismsandapotentialtarget AT yiliwu tmp21inalzheimersdiseasemolecularmechanismsandapotentialtarget AT yiliwu tmp21inalzheimersdiseasemolecularmechanismsandapotentialtarget
_version_	1724973437413228544

TMP21 in Alzheimer’s Disease: Molecular Mechanisms and a Potential Target

Similar Items