Improved metabolic response after 16 weeks of calorie-restricted low-glycaemic index diet and metformin in impaired glucose tolerance subjects

• Main Authors: Teresa Helena Macedo da Costa, Fábio Vinícius Pires da Silva, Caio Eduardo Gonçalves Reis, Luiz Augusto Casulari
• Format: Article
• Language: English
• Published: Arán Ediciones, S. L. 2014-05-01
• Series: Nutrición Hospitalaria
• Subjects: Índice glucémico; Restricción calórica; Glucosa; Metformina; Diabetes mellitus tipo 2
• Online Access: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112014000500017&lng=en&tlng=en

Aim: This study analyzed the metabolic effects of dietary advice to follow calorie-restricted low-glycaemic index diet with metformin in overweight / obese impaired glucose tolerance subjects. Methods: Sixteen subjects with body mass index between 27-38 kg/m² were followed monthly for 16 weeks and treated with metformin (1 g/day) and dietary prescription for low-glycaemic index diet with energy reduction of 25-30% their total energy expenditure. Glucose metabolism, lipid profile, anthropometric and body composition, and food intake parameters were measured before and after the treatment. Paired t-tests/Wilcoxon tests were used to compare differences from baseline, with a statistical significance criterion of p < 0.05. Results: There were significant reductions in anthropometric and body composition parameters, decrease in HOMA2-%β and triglycerides concentrations, and increase in Cederholm index. These results show enhanced peripheral insulin sensitivity and preservation of pancreatic beta-cell function. Conclusion: Calorie-restricted low-glycaemic index diet and metformin was benefit to metabolic and anthropometric parameters in overweight/obese subjects with impaired glucose tolerance.