Shear Stress Accumulation Enhances von Willebrand Factor-Induced Platelet P-Selectin Translocation in a PI3K/Akt Pathway-Dependent Manner

Shear Stress Accumulation Enhances von Willebrand Factor-Induced Platelet P-Selectin Translocation in a PI3K/Akt Pathway-Dependent Manner

Platelet adhesion and activation through the interaction of von Willebrand factor (VWF) with platelet glycoprotein (GP) Ibα are the early key events in hemostasis and thrombosis especially under high blood shear stress. P-selectin translocation from α granule to the cell surface is a typical platele...

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Bibliographic Details
Main Authors: Jinhua Fang, Xiaoxi Sun, Silu Liu, Pu Yang, Jiangguo Lin, Jingjing Feng, Miguel A. Cruz, Jing-fei Dong, Ying Fang, Jianhua Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
platelet
P-selectin
shear stress
PI3K/Akt pathway
VWF-A1 domain and its mutants
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.642108/full

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