Myoblasts With Higher IRS-1 Levels Are Eliminated From the Normal Cell Layer During Differentiation

Myoblasts With Higher IRS-1 Levels Are Eliminated From the Normal Cell Layer During Differentiation

Insulin receptor substrate (IRS)-1 is a major substrate of insulin-like growth factor (IGF)-I receptors. It is well-known that IGF-I and II play essential roles in myogenesis progression. Herein, we report an unexpected phenomenon that IRS-1-overexpressing L6 myoblasts are eliminated from normal cel...

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Bibliographic Details
Main Authors: Ryosuke Okino, Ami Usui, Yosuke Yoneyama, Shin-Ichiro Takahashi, Fumihiko Hakuno
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Endocrinology
Subjects:
insulin-like growth factor (IGF)-I
L6 myoblasts
myogenesis
insulin receptor substrate (IRS)-1
cell competition
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00096/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2020.00096/full

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