Pharmacological profiling an abundantly expressed schistosome serotonergic GPCR identifies nuciferine as a potent antagonist

Pharmacological profiling an abundantly expressed schistosome serotonergic GPCR identifies nuciferine as a potent antagonist

5-hydroxytryptamine (5-HT) is a key regulator of muscle contraction in parasitic flatworms. In Schistosoma mansoni, the myoexcitatory action of 5-HT is effected through activation of a serotonergic GPCR (Sm.5HTRL), prioritizing pharmacological characterization of this target for anthelmintic drug di...

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Bibliographic Details
Main Authors: John D. Chan, Sreemoyee Acharya, Timothy A. Day, Jonathan S. Marchant
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Natural products
Schistosomiasis
5-HT
Methoxyisoquinoline
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320716300379

Internet

http://www.sciencedirect.com/science/article/pii/S2211320716300379

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