Analysis on the relation of pterygium with VEGF,SDF-1,Ki-67,PCNA and Survivin

• Main Authors: Ying Song, Wen-Lei Yang, Lin Zhang
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2015-12-01
• Series: Guoji Yanke Zazhi
• Subjects: vascular endothelial growth factor; stroma cell-derived factor 1; tumor proliferating antigen; proliferating cell nuclear antigen; survivin; pterygium
• Online Access: http://ies.ijo.cn/cn_publish/2015/12/201512025.pdf

AIM:To analyze and study the relation of pterygium with vascular endothelial growth factor(VEGF),stroma cell-derived factor 1(SDF-1),tumor proliferating antigen(Ki-67),proliferating cell nuclear antigen(PCNA)and survivin. <p>METHODS:Seventy-nine patients(106 eyes)with pterygium from January 2013 to May 2015 in our hospital were selected as observation group. Seventy-nine persons with normal conjunctiva during the same period were selected as control group. Then the number of positive cells and staining intensity classification of the two groups for VEGF,SDF-1,Ki-67,PCNA and survivin were compared,and the detection results of patients with different gender,stages and types were compared too. Then the relation between pterygium and those indexes were analyzed by the Logistic analysis. <p>RESULTS:The number of positive cells and staining intensity classification of observation group for VEGF,SDF-1,Ki-67,PCNA and survivin were all higher than those of control group,and the detection results of patients with different stages and types had certain differences too(all <i>P</i><0.05). While the detection results of patients with different gender had no obvious differences(all <i>P</i>>0.05). All those indexes had close relation to pterygium by the Logistic analysis. <p>CONCLUSION:The expression of VEGF,SDF-1,Ki-67,PCNA and survivin in tissue of patients with pterygium all show abnormal state,and those indexes all have close relation to pterygium.