Expression of activated PIK3CA in ovarian surface epithelium results in hyperplasia but not tumor formation.

Expression of activated PIK3CA in ovarian surface epithelium results in hyperplasia but not tumor formation.

The Phosphatidylinositol 3'-kinase is a key regulator in various cancer-associated signal transduction pathways. Genetic alterations of its catalytic subunit alpha, PIK3CA, have been identified in ovarian cancer. Our in vivo data suggests that PIK3CA activation is one of the early genetic event...

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Bibliographic Details
Main Authors: Shun Liang, Nuo Yang, Yue Pan, Shan Deng, Xiaojuan Lin, Xiaojun Yang, Dionyssios Katsaros, Katherine F Roby, Thomas C Hamilton, Denise C Connolly, George Coukos, Lin Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2629728?pdf=render

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