Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training

Skeletal muscle conveys the beneficial effects of physical exercise but due to its heterogeneity, studying the effects of exercise on muscle fibres is challenging. Here, the authors carry out proteomic analysis of myofibres from freeze-dried muscle biopsies, show fibre-type specific changes in respo...

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Main Authors:	A. S. Deshmukh, D. E. Steenberg, M. Hostrup, J. B. Birk, J. K. Larsen, A. Santos, R. Kjøbsted, J. R. Hingst, C. C. Schéele, M. Murgia, B. Kiens, E. A. Richter, M. Mann, J. F. P. Wojtaszewski
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-20556-8

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spelling	doaj-00b3fadf4cc442b484a4cb9a32845cdd2021-01-17T12:13:43ZengNature Publishing GroupNature Communications2041-17232021-01-0112111510.1038/s41467-020-20556-8Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise trainingA. S. Deshmukh0D. E. Steenberg1M. Hostrup2J. B. Birk3J. K. Larsen4A. Santos5R. Kjøbsted6J. R. Hingst7C. C. Schéele8M. Murgia9B. Kiens10E. A. Richter11M. Mann12J. F. P. Wojtaszewski13The Novo Nordisk Foundation Center for Protein Research, Clinical Proteomics, Faculty of Health and Medical Sciences, University of CopenhagenSection of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of CopenhagenSection of Integrative Physiology, Department of Nutrition, Exercise and Sports, University of CopenhagenSection of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of CopenhagenThe Novo Nordisk Foundation Center for Basic Metablic Research, Faculty of Health and Medical Sciences, University of CopenhagenThe Novo Nordisk Foundation Center for Protein Research, Clinical Proteomics, Faculty of Health and Medical Sciences, University of CopenhagenSection of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of CopenhagenSection of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of CopenhagenThe Novo Nordisk Foundation Center for Basic Metablic Research, Faculty of Health and Medical Sciences, University of CopenhagenDepartment of Proteomics and Signal Transduction, Max-Planck-Institute of BiochemistrySection of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of CopenhagenSection of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of CopenhagenThe Novo Nordisk Foundation Center for Protein Research, Clinical Proteomics, Faculty of Health and Medical Sciences, University of CopenhagenSection of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of CopenhagenSkeletal muscle conveys the beneficial effects of physical exercise but due to its heterogeneity, studying the effects of exercise on muscle fibres is challenging. Here, the authors carry out proteomic analysis of myofibres from freeze-dried muscle biopsies, show fibre-type specific changes in response to exercise, and show that the oxidative and glycolytic muscle fibers adapt differentially to exercise training.https://doi.org/10.1038/s41467-020-20556-8
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	A. S. Deshmukh D. E. Steenberg M. Hostrup J. B. Birk J. K. Larsen A. Santos R. Kjøbsted J. R. Hingst C. C. Schéele M. Murgia B. Kiens E. A. Richter M. Mann J. F. P. Wojtaszewski
spellingShingle	A. S. Deshmukh D. E. Steenberg M. Hostrup J. B. Birk J. K. Larsen A. Santos R. Kjøbsted J. R. Hingst C. C. Schéele M. Murgia B. Kiens E. A. Richter M. Mann J. F. P. Wojtaszewski Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training Nature Communications
author_facet	A. S. Deshmukh D. E. Steenberg M. Hostrup J. B. Birk J. K. Larsen A. Santos R. Kjøbsted J. R. Hingst C. C. Schéele M. Murgia B. Kiens E. A. Richter M. Mann J. F. P. Wojtaszewski
author_sort	A. S. Deshmukh
title	Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training
title_short	Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training
title_full	Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training
title_fullStr	Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training
title_full_unstemmed	Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training
title_sort	deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-01-01
description	Skeletal muscle conveys the beneficial effects of physical exercise but due to its heterogeneity, studying the effects of exercise on muscle fibres is challenging. Here, the authors carry out proteomic analysis of myofibres from freeze-dried muscle biopsies, show fibre-type specific changes in response to exercise, and show that the oxidative and glycolytic muscle fibers adapt differentially to exercise training.
url	https://doi.org/10.1038/s41467-020-20556-8
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Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training

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