Pathobiology of Anaplastic Large Cell Lymphoma

Pathobiology of Anaplastic Large Cell Lymphoma

The authors revise the concept of anaplastic large cell lymphoma (ALCL) in the light of the recently updated WHO classification of Tumors of Hematopoietic and Lymphoid Tissues both on biological and clinical grounds. The main histological findings are illustrated with special reference to the cytolo...

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Main Authors: Pier Paolo Piccaluga, Anna Gazzola, Claudia Mannu, Claudio Agostinelli, Francesco Bacci, Elena Sabattini, Carlo Sagramoso, Roberto Piva, Fernando Roncolato, Giorgio Inghirami, Stefano A. Pileri
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:Advances in Hematology
Online Access:http://dx.doi.org/10.1155/2010/345053
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spelling doaj-00af575619484868a5cff5875bd4258c2021-07-02T04:39:43ZengHindawi LimitedAdvances in Hematology1687-91041687-91122010-01-01201010.1155/2010/345053345053Pathobiology of Anaplastic Large Cell LymphomaPier Paolo Piccaluga0Anna Gazzola1Claudia Mannu2Claudio Agostinelli3Francesco Bacci4Elena Sabattini5Carlo Sagramoso6Roberto Piva7Fernando Roncolato8Giorgio Inghirami9Stefano A. Pileri10Hematopathology Section, Department of Hematology and Oncological Sciences “L. and A. Seràgnoli”, S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, ItalyHematopathology Section, Department of Hematology and Oncological Sciences “L. and A. Seràgnoli”, S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, ItalyHematopathology Section, Department of Hematology and Oncological Sciences “L. and A. Seràgnoli”, S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, ItalyHematopathology Section, Department of Hematology and Oncological Sciences “L. and A. Seràgnoli”, S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, ItalyHematopathology Section, Department of Hematology and Oncological Sciences “L. and A. Seràgnoli”, S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, ItalyHematopathology Section, Department of Hematology and Oncological Sciences “L. and A. Seràgnoli”, S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, ItalyHematopathology Section, Department of Hematology and Oncological Sciences “L. and A. Seràgnoli”, S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, ItalyCenter for Experimental Research and Medical Studies (CERMS), University of Torino, 10126 Torino, ItalyHematopathology Section, Department of Hematology and Oncological Sciences “L. and A. Seràgnoli”, S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, ItalyCenter for Experimental Research and Medical Studies (CERMS), University of Torino, 10126 Torino, ItalyHematopathology Section, Department of Hematology and Oncological Sciences “L. and A. Seràgnoli”, S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, ItalyThe authors revise the concept of anaplastic large cell lymphoma (ALCL) in the light of the recently updated WHO classification of Tumors of Hematopoietic and Lymphoid Tissues both on biological and clinical grounds. The main histological findings are illustrated with special reference to the cytological spectrum that is indeed characteristic of the tumor. The phenotype is reported in detail: the expression of the ALK protein as well as the chromosomal abnormalities is discussed with their potential pathogenetic implications. The clinical features of ALCL are presented by underlining the difference in terms of response to therapy and survival between the ALK-positive and ALK-negative forms. Finally, the biological rationale for potential innovative targeted therapies is presented.http://dx.doi.org/10.1155/2010/345053
collection DOAJ
language English
format Article
sources DOAJ
author Pier Paolo Piccaluga
Anna Gazzola
Claudia Mannu
Claudio Agostinelli
Francesco Bacci
Elena Sabattini
Carlo Sagramoso
Roberto Piva
Fernando Roncolato
Giorgio Inghirami
Stefano A. Pileri
spellingShingle Pier Paolo Piccaluga
Anna Gazzola
Claudia Mannu
Claudio Agostinelli
Francesco Bacci
Elena Sabattini
Carlo Sagramoso
Roberto Piva
Fernando Roncolato
Giorgio Inghirami
Stefano A. Pileri
Pathobiology of Anaplastic Large Cell Lymphoma
Advances in Hematology
author_facet Pier Paolo Piccaluga
Anna Gazzola
Claudia Mannu
Claudio Agostinelli
Francesco Bacci
Elena Sabattini
Carlo Sagramoso
Roberto Piva
Fernando Roncolato
Giorgio Inghirami
Stefano A. Pileri
author_sort Pier Paolo Piccaluga
title Pathobiology of Anaplastic Large Cell Lymphoma
title_short Pathobiology of Anaplastic Large Cell Lymphoma
title_full Pathobiology of Anaplastic Large Cell Lymphoma
title_fullStr Pathobiology of Anaplastic Large Cell Lymphoma
title_full_unstemmed Pathobiology of Anaplastic Large Cell Lymphoma
title_sort pathobiology of anaplastic large cell lymphoma
publisher Hindawi Limited
series Advances in Hematology
issn 1687-9104
1687-9112
publishDate 2010-01-01
description The authors revise the concept of anaplastic large cell lymphoma (ALCL) in the light of the recently updated WHO classification of Tumors of Hematopoietic and Lymphoid Tissues both on biological and clinical grounds. The main histological findings are illustrated with special reference to the cytological spectrum that is indeed characteristic of the tumor. The phenotype is reported in detail: the expression of the ALK protein as well as the chromosomal abnormalities is discussed with their potential pathogenetic implications. The clinical features of ALCL are presented by underlining the difference in terms of response to therapy and survival between the ALK-positive and ALK-negative forms. Finally, the biological rationale for potential innovative targeted therapies is presented.
url http://dx.doi.org/10.1155/2010/345053
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