Association of Inflammatory and Oxidative Stress Markers with Metabolic Syndrome in Asian Indians in India

• Main Authors: Veena S. Rao, Radhika K. Nagaraj, Sridhara Hebbagodi, Natesha B. Kadarinarasimhiah, Vijay V. Kakkar
• Format: Article
• Language: English
• Published: Hindawi Limited 2011-01-01
• Series: Cardiology Research and Practice
• Online Access: http://dx.doi.org/10.4061/2011/295976

Metabolic syndrome (MetS) is a primary risk factor for cardiovascular disease and is associated with a proinflammatory state. Here, we assessed the contribution of inflammatory and oxidative stress markers towards prediction of MetS. A total of 2316 individuals were recruited in Phase I of the Indian Atherosclerosis Research Study (IARS). Modified ATPIII guidelines were used for classification of subjects with MetS. Among the inflammatory and oxidative stress markers studied, levels of hsCRP (P<.0001), Neopterin (P=.036), and oxLDL (P<.0001) were significantly higher among subjects with MetS. Among the markers we tested, oxLDL stood out as a robust predictor of MetS in the IARS population (OR 4.956 95% CI 2.504–9.810; P<.0001) followed by hsCRP (OR 1.324 95% CI 1.070–1.638; P=.010). In conclusion, oxLDL is a candidate predictor for MetS in the Asian Indian population.