Solvothermal Preparation of a Lanthanide Metal-Organic Framework for Highly Sensitive Discrimination of Nitrofurantoin and <span style="font-variant: small-caps">l</span>-Tyrosine

• Main Authors: Tian-Tian Wang, Jing-Yi Liu, Rui Guo, Jun-Dan An, Jian-Zhong Huo, Yuan-Yuan Liu, Wei Shi, Bin Ding
• Format: Article
• Language: English
• Published: MDPI AG 2021-06-01
• Series: Molecules
• Subjects: metal-organic frameworks; fluorescence; fluorescent probe; antibiotics; amino acid
• Online Access: https://www.mdpi.com/1420-3049/26/12/3673
• ISSN: 1420-3049

Metal-organic frameworks (MOFs) have been rapidly developed for their broad applications in many different chemistry and materials fields. In this work, a multi-dentate building block 5-(4-(tetrazol-5-yl)phenyl)-isophthalic acid (H₃L) containing tetrazole and carbolxylate moieties was employed for the synthesis of a two-dimensional (2D) lanthanide MOF [La(HL)(DMF)₂(NO₃)] (DMF = <i>N</i>,<i>N</i>-dimethylformamide) (<b>1</b>) under solvothermal condition. The fluorescent sensing application of <b>1</b> was investigated. <b>1</b> exhibits high sensitivity recognition for antibiotic nitrofurantoin (K_sv: 3.0 × 10³ M⁻¹ and detection limit: 17.0 μM) and amino acid <span style="font-variant: small-caps;">l</span>-tyrosine (K_sv: 1.4 × 10⁴ M⁻¹ and detection limit: 3.6 μM). This work provides a feasible detection platform of 2D MOFs for highly sensitive discrimination of antibiotics and amino acids.