Design, Synthesis, and Evaluation of Amphiphilic Cyclic and Linear Peptides Composed of Hydrophobic and Positively-Charged Amino Acids as Antibacterial Agents

Design, Synthesis, and Evaluation of Amphiphilic Cyclic and Linear Peptides Composed of Hydrophobic and Positively-Charged Amino Acids as Antibacterial Agents

Antimicrobial peptides (AMPs) contain amphipathic structures and are derived from natural resources. AMPs have been found to be effective in treating the infections caused by antibiotic-resistant bacteria (ARB), and thus, are potential lead compounds against ARB. AMPs’ physicochemical prop...

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Bibliographic Details
Main Authors: Neda Riahifard, Saghar Mozaffari, Taibah Aldakhil, Francisco Nunez, Qamar Alshammari, Saud Alshammari, Jason Yamaki, Keykavous Parang, Rakesh Kumar Tiwari
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
Subjects:
amphiphilic cyclic peptide
cationic
E. coli
hydrophobicity
methicillin-resistant Staphylococcus aureus
Online Access:http://www.mdpi.com/1420-3049/23/10/2722

Internet

http://www.mdpi.com/1420-3049/23/10/2722

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