Swept source intraoperative OCT angiography

• Main Authors: Ziyi Zhang, Tiepei Zhu, Tongtong Cao, Zhaoyu Gong, Lin Yao, Kaiyuan Liu, Juan Ye, Peng Li
• Format: Article
• Language: English
• Published: World Scientific Publishing 2021-01-01
• Series: Journal of Innovative Optical Health Sciences
• Subjects: biomedical imaging; optical coherence tomography; optical coherence tomography angiography; ophthalmology; deep anterior lamellar keratoplasty
• Online Access: http://www.worldscientific.com/doi/epdf/10.1142/S1793545821400095

To accurately guide surgical instruments during ophthalmic procedures, some necessary intraoperative depth perception is required, which standard surgical microscopes supply limitedly. Intraoperative optical coherence tomography (iOCT), combining optical coherence tomography (OCT) technology and surgical microscope, enables noninvasive, real-time and high-resolution cross-sectional imaging. Currently, though iOCT enables structural imaging, little research has been done on intraoperative angiography. In this work, we presented a swept-source intraoperative OCT angiography (SS-iOCTA) system based on a standard surgical microscope, which provides both structural and angiographic images. The feasibility of the proposed SS-iOCTA was confirmed through deep anterior lamellar keratoplasty (DALK) of ex vivo porcine eyes and blood perfusion imaging of in vivo rat cortex. High-resolution intraoperative feedback, including sub-surface structure and angiogram of biological tissue, can be visualized simultaneously with the SS-iOCTA system, which expand the surgeon’s capabilities and could be widely used in clinical surgery.