Cardioprotective effect of amlodipine in oxidative stress induced by experimental myocardial infarction in rats

The present study investigated whether the administration of amlodipine ameliorates oxidative stress induced by experimental myocardial infarction in rats. Adrenaline was administered and myocardial damage was evaluated biochemically [significantly increased serum aspertate aminotransferase (AST), l...

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Bibliographic Details
Main Authors: Sudhira Begum, Nargis Akhter
Format: Article
Language:English
Published: Bangladesh Pharmacological Society 2007-12-01
Series:Bangladesh Journal of Pharmacology
Subjects:
Online Access:http://www.bdjpharmacol.com/journalbdps0202/020255.pdf
Description
Summary:The present study investigated whether the administration of amlodipine ameliorates oxidative stress induced by experimental myocardial infarction in rats. Adrenaline was administered and myocardial damage was evaluated biochemically [significantly increased serum aspertate aminotransferase (AST), lactate dehydrogenase (LDH) and malondialdehyde (MDA) levels of myocardial tissue] and histologically (morphological changes of myocardium. Amlodipine was administered as pretreatment for 14 days in adrenaline treated rats. Statistically significant amelioration in all the biochemical parameters supported by significantly improved myocardial morphology was observed in amlodipine pretreatment. It was concluded that amlodipine afforded cardioprotection by reducing oxidative stress induced in experimental myocardial infarction of catecholamine assault.
ISSN:1991-007X
1991-0088