Pten is necessary for the quiescence and maintenance of adult muscle stem cells

Pten is necessary for the quiescence and maintenance of adult muscle stem cells

Pten is known to regulate haematopoietic stem cell functions. Here the authors show that Ptenalteration of Notch signalling has stage-specific muscle regenerative functions in muscle stem cells by preventing premature differentiation of quiescent cells and enhancing the self-renewal of activated cel...

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Main Authors: Feng Yue, Pengpeng Bi, Chao Wang, Tizhong Shan, Yaohui Nie, Timothy L. Ratliff, Timothy P. Gavin, Shihuan Kuang
Format: Article
Language:English
Published: Nature Publishing Group 2017-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14328
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spelling doaj-00969596d127462ca70e44a0269cbe232021-05-11T07:21:23ZengNature Publishing GroupNature Communications2041-17232017-01-018111310.1038/ncomms14328Pten is necessary for the quiescence and maintenance of adult muscle stem cellsFeng Yue0Pengpeng Bi1Chao Wang2Tizhong Shan3Yaohui Nie4Timothy L. Ratliff5Timothy P. Gavin6Shihuan Kuang7Department of Animal Sciences, Purdue University, 901 W State StreetDepartment of Animal Sciences, Purdue University, 901 W State StreetDepartment of Animal Sciences, Purdue University, 901 W State StreetDepartment of Animal Sciences, Purdue University, 901 W State StreetDepartment of Animal Sciences, Purdue University, 901 W State StreetCenter for Cancer Research, Purdue UniversityDepartment of Health and Kinesiology, Purdue UniversityDepartment of Animal Sciences, Purdue University, 901 W State StreetPten is known to regulate haematopoietic stem cell functions. Here the authors show that Ptenalteration of Notch signalling has stage-specific muscle regenerative functions in muscle stem cells by preventing premature differentiation of quiescent cells and enhancing the self-renewal of activated cells.https://doi.org/10.1038/ncomms14328
collection DOAJ
language English
format Article
sources DOAJ
author Feng Yue
Pengpeng Bi
Chao Wang
Tizhong Shan
Yaohui Nie
Timothy L. Ratliff
Timothy P. Gavin
Shihuan Kuang
spellingShingle Feng Yue
Pengpeng Bi
Chao Wang
Tizhong Shan
Yaohui Nie
Timothy L. Ratliff
Timothy P. Gavin
Shihuan Kuang
Pten is necessary for the quiescence and maintenance of adult muscle stem cells
Nature Communications
author_facet Feng Yue
Pengpeng Bi
Chao Wang
Tizhong Shan
Yaohui Nie
Timothy L. Ratliff
Timothy P. Gavin
Shihuan Kuang
author_sort Feng Yue
title Pten is necessary for the quiescence and maintenance of adult muscle stem cells
title_short Pten is necessary for the quiescence and maintenance of adult muscle stem cells
title_full Pten is necessary for the quiescence and maintenance of adult muscle stem cells
title_fullStr Pten is necessary for the quiescence and maintenance of adult muscle stem cells
title_full_unstemmed Pten is necessary for the quiescence and maintenance of adult muscle stem cells
title_sort pten is necessary for the quiescence and maintenance of adult muscle stem cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-01-01
description Pten is known to regulate haematopoietic stem cell functions. Here the authors show that Ptenalteration of Notch signalling has stage-specific muscle regenerative functions in muscle stem cells by preventing premature differentiation of quiescent cells and enhancing the self-renewal of activated cells.
url https://doi.org/10.1038/ncomms14328
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