Evaluation of 1β-Hydroxylation of Deoxycholic Acid as a Non-Invasive Urinary Biomarker of CYP3A Activity in the Assessment of Inhibition-Based Drug–Drug Interaction in Healthy Volunteers

Evaluation of 1β-Hydroxylation of Deoxycholic Acid as a Non-Invasive Urinary Biomarker of CYP3A Activity in the Assessment of Inhibition-Based Drug–Drug Interaction in Healthy Volunteers

In this study, we aimed to evaluate the utility of endogenous 1β-hydroxy-deoxycholic acid/total deoxycholic acid ratio (1β-OH-DCA/ToDCA) in spot urine as a surrogate marker of cytochrome P450 3A (CYP3A) activity in the assessment inhibition-based drug–drug interactions in healthy volunteers. This wa...

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Bibliographic Details
Main Authors: Xue-Qing Li, Roslyn Stella Thelingwani, Leif Bertilsson, Ulf Diczfalusy, Tommy B. Andersson, Collen Masimirembwa
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Journal of Personalized Medicine
Subjects:
CYP3A
biomarker
human
deoxycholic acid
1β-hydroxy-deoxycholic acid
urine
Online Access:https://www.mdpi.com/2075-4426/11/6/457

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