Bimodal sensing of guidance cues in mechanically distinct microenvironments

Bimodal sensing of guidance cues in mechanically distinct microenvironments

Invasive cells respond to contact guidance cues during migration. Here, using micro- and nanopatterning with different ligands and varying stiffness, the authors find that cells can make cellular protrusions through both contractility-dependent and contractility-independent means.

Bibliographic Details
Main Authors: Erdem D. Tabdanov, Vikram V. Puram, Zaw Win, Ashab Alamgir, Patrick W. Alford, Paolo P. Provenzano
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07290-y
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spelling doaj-0089919579e3475c95e212fc5fe23d0a2021-05-11T10:32:12ZengNature Publishing GroupNature Communications2041-17232018-11-019111810.1038/s41467-018-07290-yBimodal sensing of guidance cues in mechanically distinct microenvironmentsErdem D. Tabdanov0Vikram V. Puram1Zaw Win2Ashab Alamgir3Patrick W. Alford4Paolo P. Provenzano5Department of Biomedical Engineering, University of MinnesotaDepartment of Biomedical Engineering, University of MinnesotaDepartment of Biomedical Engineering, University of MinnesotaDepartment of Biomedical Engineering, University of MinnesotaDepartment of Biomedical Engineering, University of MinnesotaDepartment of Biomedical Engineering, University of MinnesotaInvasive cells respond to contact guidance cues during migration. Here, using micro- and nanopatterning with different ligands and varying stiffness, the authors find that cells can make cellular protrusions through both contractility-dependent and contractility-independent means.https://doi.org/10.1038/s41467-018-07290-y
collection DOAJ
language English
format Article
sources DOAJ
author Erdem D. Tabdanov
Vikram V. Puram
Zaw Win
Ashab Alamgir
Patrick W. Alford
Paolo P. Provenzano
spellingShingle Erdem D. Tabdanov
Vikram V. Puram
Zaw Win
Ashab Alamgir
Patrick W. Alford
Paolo P. Provenzano
Bimodal sensing of guidance cues in mechanically distinct microenvironments
Nature Communications
author_facet Erdem D. Tabdanov
Vikram V. Puram
Zaw Win
Ashab Alamgir
Patrick W. Alford
Paolo P. Provenzano
author_sort Erdem D. Tabdanov
title Bimodal sensing of guidance cues in mechanically distinct microenvironments
title_short Bimodal sensing of guidance cues in mechanically distinct microenvironments
title_full Bimodal sensing of guidance cues in mechanically distinct microenvironments
title_fullStr Bimodal sensing of guidance cues in mechanically distinct microenvironments
title_full_unstemmed Bimodal sensing of guidance cues in mechanically distinct microenvironments
title_sort bimodal sensing of guidance cues in mechanically distinct microenvironments
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-11-01
description Invasive cells respond to contact guidance cues during migration. Here, using micro- and nanopatterning with different ligands and varying stiffness, the authors find that cells can make cellular protrusions through both contractility-dependent and contractility-independent means.
url https://doi.org/10.1038/s41467-018-07290-y
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AT vikramvpuram bimodalsensingofguidancecuesinmechanicallydistinctmicroenvironments
AT zawwin bimodalsensingofguidancecuesinmechanicallydistinctmicroenvironments
AT ashabalamgir bimodalsensingofguidancecuesinmechanicallydistinctmicroenvironments
AT patrickwalford bimodalsensingofguidancecuesinmechanicallydistinctmicroenvironments
AT paolopprovenzano bimodalsensingofguidancecuesinmechanicallydistinctmicroenvironments
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