Human Keratinocytes Inhibit CD4<sup>+</sup> T-Cell Proliferation through TGFB1 Secretion and Surface Expression of HLA-G1 and PD-L1 Immune Checkpoints

Human Keratinocytes Inhibit CD4<sup>+</sup> T-Cell Proliferation through TGFB1 Secretion and Surface Expression of HLA-G1 and PD-L1 Immune Checkpoints

Human skin protects the body against infection and injury. This protection involves immune and epithelial cells, but their interactions remain largely unknown. Here, we show that cultured epidermal keratinocytes inhibit allogenic CD4<sup>+</sup> T-cell proliferation under both normal and...

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Bibliographic Details
Main Authors: Guillaume Mestrallet, Frédéric Auvré, Chantal Schenowitz, Edgardo D. Carosella, Joel LeMaoult, Michèle T. Martin, Nathalie Rouas-Freiss, Nicolas O. Fortunel
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
skin immunity
human keratinocytes
immunomodulation
HLA-G1
PD-L1
TGFB1
Online Access:https://www.mdpi.com/2073-4409/10/6/1438

Internet

https://www.mdpi.com/2073-4409/10/6/1438

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