Sulfur-containing heterocyclic compounds with potential antidiabetic activity

The essential link in the pathogenesis of diabetes mellitus and its complications is a non-enzymatic glycosylation of proteins. However, modern endocrinology lacks of clinically effective pharmaceuticals for its correction. The screening of 23 derivatives of 1,3,4-thiadiazine the ability to inhibit...

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Main Authors:	E. A. Savateeva, V. V. Emelyanov, A. V. Musalnikova, L. P. Sidorova, N. E. Maksimova, N. N. Machulskaya, V. A. Chereshnev
Format:	Article
Language:	English
Published:	Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina 2014-12-01
Series:	Chimica Techno Acta
Subjects:	1,3,4-Тиадиазины противодиабетическая активность неферментативное гликозилирование белков скрининг структура-активность
Online Access:	https://journals.urfu.ru/index.php/chimtech/article/view/1161

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spelling	doaj-008059b272434232b434dd5798b4ba3c2020-11-24T23:17:52ZengUralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina Chimica Techno Acta2409-56132411-14142014-12-0113838610.15826/chimtech.2014.1.3.11611108Sulfur-containing heterocyclic compounds with potential antidiabetic activityE. A. Savateeva0V. V. Emelyanov1A. V. Musalnikova2L. P. Sidorova3N. E. Maksimova4N. N. Machulskaya5V. A. Chereshnev6Ural Federal University, EkaterinburgUral Federal University, EkaterinburgUral Federal University, EkaterinburgUral Federal University, EkaterinburgUral Federal University, EkaterinburgUral Federal University, EkaterinburgInstitute of Immunology and Physiology UBRAS, Ural federal university, EkaterinburgThe essential link in the pathogenesis of diabetes mellitus and its complications is a non-enzymatic glycosylation of proteins. However, modern endocrinology lacks of clinically effective pharmaceuticals for its correction. The screening of 23 derivatives of 1,3,4-thiadiazine the ability to inhibit the reaction of non-enzymatic glycosylation of proteins in vitro was held, and 11 the most active compounds of them were selected, also the relationship «structure – activity» was investigated. An essential part of the pathogenesis of diabetes mellitus and its complications is non-enzymatic glycosylation of proteins. However, modern endocrinology lacks clinically effective medicines for its correction.https://journals.urfu.ru/index.php/chimtech/article/view/11611,3,4-Тиадиазиныпротиводиабетическая активностьнеферментативное гликозилирование белковскринингструктура-активность
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	E. A. Savateeva V. V. Emelyanov A. V. Musalnikova L. P. Sidorova N. E. Maksimova N. N. Machulskaya V. A. Chereshnev
spellingShingle	E. A. Savateeva V. V. Emelyanov A. V. Musalnikova L. P. Sidorova N. E. Maksimova N. N. Machulskaya V. A. Chereshnev Sulfur-containing heterocyclic compounds with potential antidiabetic activity Chimica Techno Acta 1,3,4-Тиадиазины противодиабетическая активность неферментативное гликозилирование белков скрининг структура-активность
author_facet	E. A. Savateeva V. V. Emelyanov A. V. Musalnikova L. P. Sidorova N. E. Maksimova N. N. Machulskaya V. A. Chereshnev
author_sort	E. A. Savateeva
title	Sulfur-containing heterocyclic compounds with potential antidiabetic activity
title_short	Sulfur-containing heterocyclic compounds with potential antidiabetic activity
title_full	Sulfur-containing heterocyclic compounds with potential antidiabetic activity
title_fullStr	Sulfur-containing heterocyclic compounds with potential antidiabetic activity
title_full_unstemmed	Sulfur-containing heterocyclic compounds with potential antidiabetic activity
title_sort	sulfur-containing heterocyclic compounds with potential antidiabetic activity
publisher	Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina
series	Chimica Techno Acta
issn	2409-5613 2411-1414
publishDate	2014-12-01
description	The essential link in the pathogenesis of diabetes mellitus and its complications is a non-enzymatic glycosylation of proteins. However, modern endocrinology lacks of clinically effective pharmaceuticals for its correction. The screening of 23 derivatives of 1,3,4-thiadiazine the ability to inhibit the reaction of non-enzymatic glycosylation of proteins in vitro was held, and 11 the most active compounds of them were selected, also the relationship «structure – activity» was investigated. An essential part of the pathogenesis of diabetes mellitus and its complications is non-enzymatic glycosylation of proteins. However, modern endocrinology lacks clinically effective medicines for its correction.
topic	1,3,4-Тиадиазины противодиабетическая активность неферментативное гликозилирование белков скрининг структура-активность
url	https://journals.urfu.ru/index.php/chimtech/article/view/1161
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Sulfur-containing heterocyclic compounds with potential antidiabetic activity

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