Improved mass spectrometry-based activity assay reveals oxidative and metabolic stress as sirtuin-1 regulators

Improved mass spectrometry-based activity assay reveals oxidative and metabolic stress as sirtuin-1 regulators

Sirtuin-1 (SirT1) catalyzes NAD+-dependent protein lysine deacetylation and is a critical regulator of energy and lipid metabolism, mitochondrial biogenesis, apoptosis, and senescence. Activation of SirT1 mitigates metabolic perturbations associated with diabetes and obesity. Pharmacologic molecules...

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Bibliographic Details
Main Authors: Di Shao, Chunxiang Yao, Maya H. Kim, Jessica Fry, Richard A. Cohen, Catherine E. Costello, Reiko Matsui, Francesca Seta, Mark E. McComb, Markus M. Bachschmid
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718310437

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