Control of AMPA receptor activity by the extracellular loops of auxiliary proteins

Control of AMPA receptor activity by the extracellular loops of auxiliary proteins

At synapses throughout the mammalian brain, AMPA receptors form complexes with auxiliary proteins, including TARPs. However, how TARPs modulate AMPA receptor gating remains poorly understood. We built structural models of TARP-AMPA receptor complexes for TARPs γ2 and γ8, combining recent structural...

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Bibliographic Details
Main Authors: Irene Riva, Clarissa Eibl, Rudolf Volkmer, Anna L Carbone, Andrew JR Plested
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
receptor kinetics
modulation
superactivation
desensitization
glutamate
Online Access:https://elifesciences.org/articles/28680

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