3D-printed nerve guidance conduits multi-functionalized with canine multipotent mesenchymal stromal cells promote neuroregeneration after sciatic nerve injury in rats

3D-printed nerve guidance conduits multi-functionalized with canine multipotent mesenchymal stromal cells promote neuroregeneration after sciatic nerve injury in rats

Abstract Background Nerve injuries are debilitating, leading to long-term motor deficits. Remyelination and axonal growth are supported and enhanced by growth factor and cytokines. Combination of nerve guidance conduits (NGCs) with adipose-tissue-derived multipotent mesenchymal stromal cells (AdMSCs...

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Bibliographic Details
Main Authors: Diego Noé Rodríguez-Sánchez, Giovana Boff Araujo Pinto, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues de Oliveira, Ana Livia Carvalho Bovolato, Marcio de Carvalho, Jorge Vicente Lopes da Silva, Janaina de Andréa Dernowsek, Marjorie Golim, Benedito Barraviera, Rui Seabra Ferreira, Elenice Deffune, Mathues Bertanha, Rogério Martins Amorim
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Stem Cell Research & Therapy
Subjects:
Canine mesenchymal stem cells
Nerve regeneration
Sciatic nerve injury
Cell-based therapy
Tissue engineering
Nerve guidance conduits
Online Access:https://doi.org/10.1186/s13287-021-02315-8

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