Mutational Evolution of Pseudomonas aeruginosa Resistance to Ribosome-Targeting Antibiotics

Mutational Evolution of Pseudomonas aeruginosa Resistance to Ribosome-Targeting Antibiotics

The present work examines the evolutionary trajectories of replicate Pseudomonas aeruginosa cultures in presence of the ribosome-targeting antibiotics tobramycin and tigecycline. It is known that large number of mutations across different genes – and therefore a large number of potential pathways –...

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Bibliographic Details
Main Authors: Fernando Sanz-García, Sara Hernando-Amado, José L. Martínez
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Genetics
Subjects:
antibiotic resistance
Pseudomonas aeruginosa
tobramycin
tigecycline
mutation
evolution
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00451/full

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