Combined aliskiren and L-arginine treatment has antihypertensive effects and prevents vascular endothelial dysfunction in a model of renovascular hypertension

Combined aliskiren and L-arginine treatment has antihypertensive effects and prevents vascular endothelial dysfunction in a model of renovascular hypertension

Angiotensin II is a key player in the pathogenesis of renovascular hypertension, a condition associated with endothelial dysfunction. We investigated aliskiren (ALSK) and L-arginine treatment both alone and in combination on blood pressure (BP), and vascular reactivity in aortic rings. Hypertension...

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Bibliographic Details
Main Authors: C.H. Santuzzi, R.V. Tiradentes, V. Mengal, E.R.G. Claudio, H. Mauad, S.A. Gouvea, G.R. Abreu
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2015-01-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
2K1C hypertension
endothelial dysfunction
aliskiren
L-arginine
RAAS and oxidative stress
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000100065&lng=en&tlng=en

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