The EPA Cancer Risk Assessment Default Model Proposal: Moving Away From the LNT

The EPA Cancer Risk Assessment Default Model Proposal: Moving Away From the LNT

This article strongly supports the Environmental Protection Agency proposal to make significant changes in their cancer risk assessment principles and practices by moving away from the use of the linear nonthreshold (LNT) dose–response as the default model. An alternate approach is proposed based on...

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Bibliographic Details
Main Authors: Edward J. Calabrese, Jaap C. Hanekamp, Dima Yazji Shamoun
Format: Article
Language:English
Published: SAGE Publishing 2018-08-01
Series:Dose-Response
Online Access:https://doi.org/10.1177/1559325818789840
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spelling doaj-00568e0fd1ba480e80ed0856d5f30a052020-11-25T03:34:38ZengSAGE PublishingDose-Response1559-32582018-08-011610.1177/1559325818789840The EPA Cancer Risk Assessment Default Model Proposal: Moving Away From the LNTEdward J. Calabrese0Jaap C. Hanekamp1Dima Yazji Shamoun2 Department of Environmental Health Sciences, University of Massachusetts, Amherst, MA, USA Science Department, University College Roosevelt, Middelburg, The Netherlands Economics Department, University of Texas at Austin, Austin, TX, USAThis article strongly supports the Environmental Protection Agency proposal to make significant changes in their cancer risk assessment principles and practices by moving away from the use of the linear nonthreshold (LNT) dose–response as the default model. An alternate approach is proposed based on model uncertainty which integrates the most scientifically supportable features of the threshold, hormesis, and LNT models to identify the doses that optimize population-based responses (ie, maximize health benefits/minimize health harm). This novel approach for cancer risk assessment represents a significant improvement to the current LNT default method from scientific and public health perspectives.https://doi.org/10.1177/1559325818789840
collection DOAJ
language English
format Article
sources DOAJ
author Edward J. Calabrese
Jaap C. Hanekamp
Dima Yazji Shamoun
spellingShingle Edward J. Calabrese
Jaap C. Hanekamp
Dima Yazji Shamoun
The EPA Cancer Risk Assessment Default Model Proposal: Moving Away From the LNT
Dose-Response
author_facet Edward J. Calabrese
Jaap C. Hanekamp
Dima Yazji Shamoun
author_sort Edward J. Calabrese
title The EPA Cancer Risk Assessment Default Model Proposal: Moving Away From the LNT
title_short The EPA Cancer Risk Assessment Default Model Proposal: Moving Away From the LNT
title_full The EPA Cancer Risk Assessment Default Model Proposal: Moving Away From the LNT
title_fullStr The EPA Cancer Risk Assessment Default Model Proposal: Moving Away From the LNT
title_full_unstemmed The EPA Cancer Risk Assessment Default Model Proposal: Moving Away From the LNT
title_sort epa cancer risk assessment default model proposal: moving away from the lnt
publisher SAGE Publishing
series Dose-Response
issn 1559-3258
publishDate 2018-08-01
description This article strongly supports the Environmental Protection Agency proposal to make significant changes in their cancer risk assessment principles and practices by moving away from the use of the linear nonthreshold (LNT) dose–response as the default model. An alternate approach is proposed based on model uncertainty which integrates the most scientifically supportable features of the threshold, hormesis, and LNT models to identify the doses that optimize population-based responses (ie, maximize health benefits/minimize health harm). This novel approach for cancer risk assessment represents a significant improvement to the current LNT default method from scientific and public health perspectives.
url https://doi.org/10.1177/1559325818789840
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