Oropharyngeal mucosal transmission of Zika virus in rhesus macaques
Zika virus (ZIKV) is present in body fluids, including saliva, but transmission risk through mucosal contact is not well known. Here, the authors show that oropharyngeal mucosal infection of macaques with a high ZIKV dose results in viremia, but that transmission risk from saliva of infected animals...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2017-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00246-8 |
| id |
doaj-00564ee8a1ce45af98f5098b776f6d85 |
|---|---|
| record_format |
Article |
| spelling |
doaj-00564ee8a1ce45af98f5098b776f6d852021-01-31T12:37:47ZengNature Publishing GroupNature Communications2041-17232017-08-01811710.1038/s41467-017-00246-8Oropharyngeal mucosal transmission of Zika virus in rhesus macaquesChristina M. Newman0Dawn M. Dudley1Matthew T. Aliota2Andrea M. Weiler3Gabrielle L. Barry4Mariel S. Mohns5Meghan E. Breitbach6Laurel M. Stewart7Connor R. Buechler8Michael E. Graham9Jennifer Post10Nancy Schultz-Darken11Eric Peterson12Wendy Newton13Emma L. Mohr14Saverio Capuano15David H. O’Connor16Thomas C. Friedrich17Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public HealthDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public HealthDepartment of Pathobiological Sciences, University of Wisconsin School of Veterinary MedicineWisconsin National Primate Research Center, University of WisconsinWisconsin National Primate Research Center, University of WisconsinDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public HealthDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public HealthDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public HealthDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public HealthDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public HealthWisconsin National Primate Research Center, University of WisconsinWisconsin National Primate Research Center, University of WisconsinWisconsin National Primate Research Center, University of WisconsinWisconsin National Primate Research Center, University of WisconsinDepartment of Pediatrics, University of Wisconsin, University of Wisconsin Clinical Science CenterWisconsin National Primate Research Center, University of WisconsinDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public HealthDepartment of Pathobiological Sciences, University of Wisconsin School of Veterinary MedicineZika virus (ZIKV) is present in body fluids, including saliva, but transmission risk through mucosal contact is not well known. Here, the authors show that oropharyngeal mucosal infection of macaques with a high ZIKV dose results in viremia, but that transmission risk from saliva of infected animals is low.https://doi.org/10.1038/s41467-017-00246-8 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Christina M. Newman Dawn M. Dudley Matthew T. Aliota Andrea M. Weiler Gabrielle L. Barry Mariel S. Mohns Meghan E. Breitbach Laurel M. Stewart Connor R. Buechler Michael E. Graham Jennifer Post Nancy Schultz-Darken Eric Peterson Wendy Newton Emma L. Mohr Saverio Capuano David H. O’Connor Thomas C. Friedrich |
| spellingShingle |
Christina M. Newman Dawn M. Dudley Matthew T. Aliota Andrea M. Weiler Gabrielle L. Barry Mariel S. Mohns Meghan E. Breitbach Laurel M. Stewart Connor R. Buechler Michael E. Graham Jennifer Post Nancy Schultz-Darken Eric Peterson Wendy Newton Emma L. Mohr Saverio Capuano David H. O’Connor Thomas C. Friedrich Oropharyngeal mucosal transmission of Zika virus in rhesus macaques Nature Communications |
| author_facet |
Christina M. Newman Dawn M. Dudley Matthew T. Aliota Andrea M. Weiler Gabrielle L. Barry Mariel S. Mohns Meghan E. Breitbach Laurel M. Stewart Connor R. Buechler Michael E. Graham Jennifer Post Nancy Schultz-Darken Eric Peterson Wendy Newton Emma L. Mohr Saverio Capuano David H. O’Connor Thomas C. Friedrich |
| author_sort |
Christina M. Newman |
| title |
Oropharyngeal mucosal transmission of Zika virus in rhesus macaques |
| title_short |
Oropharyngeal mucosal transmission of Zika virus in rhesus macaques |
| title_full |
Oropharyngeal mucosal transmission of Zika virus in rhesus macaques |
| title_fullStr |
Oropharyngeal mucosal transmission of Zika virus in rhesus macaques |
| title_full_unstemmed |
Oropharyngeal mucosal transmission of Zika virus in rhesus macaques |
| title_sort |
oropharyngeal mucosal transmission of zika virus in rhesus macaques |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-08-01 |
| description |
Zika virus (ZIKV) is present in body fluids, including saliva, but transmission risk through mucosal contact is not well known. Here, the authors show that oropharyngeal mucosal infection of macaques with a high ZIKV dose results in viremia, but that transmission risk from saliva of infected animals is low. |
| url |
https://doi.org/10.1038/s41467-017-00246-8 |
| work_keys_str_mv |
AT christinamnewman oropharyngealmucosaltransmissionofzikavirusinrhesusmacaques AT dawnmdudley oropharyngealmucosaltransmissionofzikavirusinrhesusmacaques AT matthewtaliota oropharyngealmucosaltransmissionofzikavirusinrhesusmacaques AT andreamweiler oropharyngealmucosaltransmissionofzikavirusinrhesusmacaques AT gabriellelbarry oropharyngealmucosaltransmissionofzikavirusinrhesusmacaques AT marielsmohns oropharyngealmucosaltransmissionofzikavirusinrhesusmacaques AT meghanebreitbach oropharyngealmucosaltransmissionofzikavirusinrhesusmacaques AT laurelmstewart oropharyngealmucosaltransmissionofzikavirusinrhesusmacaques AT connorrbuechler oropharyngealmucosaltransmissionofzikavirusinrhesusmacaques AT michaelegraham oropharyngealmucosaltransmissionofzikavirusinrhesusmacaques AT jenniferpost oropharyngealmucosaltransmissionofzikavirusinrhesusmacaques AT nancyschultzdarken oropharyngealmucosaltransmissionofzikavirusinrhesusmacaques AT ericpeterson oropharyngealmucosaltransmissionofzikavirusinrhesusmacaques AT wendynewton oropharyngealmucosaltransmissionofzikavirusinrhesusmacaques AT emmalmohr oropharyngealmucosaltransmissionofzikavirusinrhesusmacaques AT saveriocapuano oropharyngealmucosaltransmissionofzikavirusinrhesusmacaques AT davidhoconnor oropharyngealmucosaltransmissionofzikavirusinrhesusmacaques AT thomascfriedrich oropharyngealmucosaltransmissionofzikavirusinrhesusmacaques |
| _version_ |
1724317140166639616 |