Changes in arterial blood pressure after single oral administration of cuttlefish (Sepia officinalis) muscle derived peptides in spontaneously hypertensive rats

• Main Authors: Rafik Balti, Ali Bougatef, Didier Guillochon, Pascal Dhulster, Moncef Nasri, Naima Nedjar-Arroume
• Format: Article
• Language: English
• Published: Elsevier 2012-07-01
• Series: Journal of Functional Foods
• Subjects: Antihypertensive peptides; Cuttlefish muscle; Sepia officinalis; Arterial blood pressure; Spontaneously hypertensive rats
• Online Access: http://www.sciencedirect.com/science/article/pii/S1756464612000485
• ISSN: 1756-4646

In this study we evaluated the short-term oral antihypertensive effect of several peptide sequences isolated from cuttlefish (Sepia officinalis) muscle proteins hydrolysates, previously characterized as in vitro angiotensin-I-converting enzyme-inhibitors, in spontaneously hypertensive rats (SHR). Systolic blood pressure (SBP) and the diastolic blood pressure (DBP) of the rats were measured by the tail cuff method before administration and also 2, 4, 6, 8 and 24 h post-administration. The peptide sequences Val-Tyr-Ala-Pro, Val-Ile-Ile-Phe and Ala-His-Ser-Tyr showed a clear decrease in SBP and DBP in SHR. Met-Ala-Trp caused a significant decrease of the SBP in the SHR, but this sequence caused a slight decrease in DBP in these animals. SBP and DBP returned to baseline values 24 h post-administration of all peptides. Thus, these peptides are bioactive ingredients with potential benefit in the prevention and treatment of hypertension.