Expansion of Knowledge on OCT1 Variant Activity In Vitro and In Vivo Using Oct1/2−/− Mice

Expansion of Knowledge on OCT1 Variant Activity In Vitro and In Vivo Using Oct1/2−/− Mice

The role of organic cation transporter 1 (OCT1) in humans is gaining attention as data emerges regarding its role in physiology, drug exposure, and drug response. OCT1 variants with decreased in vitro function correlate well with altered exposure of multiple OCT1 substrates in variant carriers. In t...

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Bibliographic Details
Main Authors: Bridget L. Morse, Lisa Hong Chen, John T. Catlow, John K. Fallon, Philip C. Smith, Kathleen M. Hillgren
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
drug transport
organic cation transporter 1 (OCT1)
pharmacokinetics
knockout mice
metabolite kinetics
targeted proteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.631793/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.631793/full

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