A positive feed-forward loop between LncRNA-URRCC and EGFL7/P-AKT/FOXO3 signaling promotes proliferation and metastasis of clear cell renal cell carcinoma

A positive feed-forward loop between LncRNA-URRCC and EGFL7/P-AKT/FOXO3 signaling promotes proliferation and metastasis of clear cell renal cell carcinoma

Abstract Background The aberrant expression of long noncoding RNAs (lncRNAs) has recently emerged as key molecules in human cancers; however, whether lncRNAs are implicated in the progression of clear cell renal cell carcinoma (ccRCC) remains unclear. Methods Candidate lncRNAs were selected using mi...

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Bibliographic Details
Main Authors: Wei Zhai, Rujian Zhu, Junjie Ma, Dongkui Gong, Haimin Zhang, Jin Zhang, Yonghui Chen, Yiran Huang, Junhua Zheng, Wei Xue
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Molecular Cancer
Subjects:
Clear cell renal cell carcinoma
Long noncoding RNA
Proliferation
Invasion
EGFL7
FOXO3
Online Access:http://link.springer.com/article/10.1186/s12943-019-0998-y

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