SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS

SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS

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Abstract. Salmon soft roe DNA influence on healthy donors blood cells secretion of early hemopoietic factors (IL-3, GM-CSF, TNFα) as well as biologically active substance influence on cytokine balance of Тh1 and Тh2 responses (IFNγ, IL-10) in vitro was studied. It is established, that DNA has modula...

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Main Author: L. N. Fedjanina
Format: Article
Language:Russian
Published: SPb RAACI 2014-07-01
Series:Medicinskaâ Immunologiâ
Subjects:
salmon soft roe dna
cytokines
healthy donors
lymphocytes
lymphocytes subpopulations
Online Access:https://www.mimmun.ru/mimmun/article/view/654
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spelling doaj-0034f2fa925040bb90883bfd73ecec452021-07-29T09:02:28ZrusSPb RAACIMedicinskaâ Immunologiâ1563-06252313-741X2014-07-0175-661761910.15789/1563-0625-2005-5-6-617-619651SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORSL. N. Fedjanina0Научно–исследовательский институт эпидемиологии и микробиологии СО РАМН, г. ВладивостокAbstract. Salmon soft roe DNA influence on healthy donors blood cells secretion of early hemopoietic factors (IL-3, GM-CSF, TNFα) as well as biologically active substance influence on cytokine balance of Тh1 and Тh2 responses (IFNγ, IL-10) in vitro was studied. It is established, that DNA has modulatory effect on secretion of all investigated cytokines - IL-3, GM-CSF, TNFα, INFγ and IL-10 by blood cells of healthy donors, increases their initially low concentration, reduces initially high and does not have essential influence at an average level of their secretion. Under action of DNA IFNγ level (stimulation index=3,3) increases more significantly than IL-10 level (stimulation index =1,9). Thus, salmon soft roe DNA possesses immunomodulatory properties.https://www.mimmun.ru/mimmun/article/view/654salmon soft roe dnacytokineshealthy donorslymphocyteslymphocytes subpopulations
collection DOAJ
language Russian
format Article
sources DOAJ
author L. N. Fedjanina
spellingShingle L. N. Fedjanina
SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS
Medicinskaâ Immunologiâ
salmon soft roe dna
cytokines
healthy donors
lymphocytes
lymphocytes subpopulations
author_facet L. N. Fedjanina
author_sort L. N. Fedjanina
title SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS
title_short SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS
title_full SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS
title_fullStr SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS
title_full_unstemmed SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS
title_sort salmon soft roe dna on blood cells secretion of cytokines in healthy donors
publisher SPb RAACI
series Medicinskaâ Immunologiâ
issn 1563-0625
2313-741X
publishDate 2014-07-01
description Abstract. Salmon soft roe DNA influence on healthy donors blood cells secretion of early hemopoietic factors (IL-3, GM-CSF, TNFα) as well as biologically active substance influence on cytokine balance of Тh1 and Тh2 responses (IFNγ, IL-10) in vitro was studied. It is established, that DNA has modulatory effect on secretion of all investigated cytokines - IL-3, GM-CSF, TNFα, INFγ and IL-10 by blood cells of healthy donors, increases their initially low concentration, reduces initially high and does not have essential influence at an average level of their secretion. Under action of DNA IFNγ level (stimulation index=3,3) increases more significantly than IL-10 level (stimulation index =1,9). Thus, salmon soft roe DNA possesses immunomodulatory properties.
topic salmon soft roe dna
cytokines
healthy donors
lymphocytes
lymphocytes subpopulations
url https://www.mimmun.ru/mimmun/article/view/654
work_keys_str_mv AT lnfedjanina salmonsoftroednaonbloodcellssecretionofcytokinesinhealthydonors
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