Distinct Molecular Mechanisms Underlying Potassium Efflux for NLRP3 Inflammasome Activation

Distinct Molecular Mechanisms Underlying Potassium Efflux for NLRP3 Inflammasome Activation

The NLRP3 inflammasome is a core component of innate immunity, and dysregulation of NLRP3 inflammasome involves developing autoimmune, metabolic, and neurodegenerative diseases. Potassium efflux has been reported to be essential for NLRP3 inflammasome activation by structurally diverse pathogen-asso...

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Bibliographic Details
Main Authors: Ziwei Xu, Zi-mo Chen, Xiaoyan Wu, Linjie Zhang, Ying Cao, Pingzheng Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
P2X7 receptor
pannexin-1
Gasdermin D
K2P channels
TWIK protein-related acid-sensitive potassium channel 2
THIK-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.609441/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.609441/full

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